5 syllables: Dex, a, meth, a, sone. Stress on meth.
dek-suh-METH-uh-sohn
/ˌdɛk.səˈmɛθəˌsoʊn/
Dexamethasone is pronounced dek-suh-METH-uh-sohn (/ˌdɛk.səˈmɛθəˌsoʊn/). It has five syllables (Dex-a-meth-a-sone), with the stress on "meth". Dexamethasone is a potent synthetic glucocorticoid used as an anti-inflammatory and immunosuppressant. It is administered in various doses for conditions ranging from allergies to autoimmune diseases and certain cancers. The word is derived from the chemical naming conventions for corticosteroids and is commonly encountered in medical contexts and pharmacology literature.
nounDexamethasone is a potent synthetic glucocorticoid used as an anti-inflammatory and immunosuppressant. It is administered in various doses for conditions ranging from allergies to autoimmune diseases and certain cancers. The word is derived from the chemical naming conventions for corticosteroids and is commonly encountered in medical contexts and pharmacology literature.
How to Pronounce Dexamethasone
"The patient was prescribed dexamethasone to reduce cerebral edema."
"Researchers studied dexamethasone as part of a trial for inflammatory lung disease."
"Dexamethasone can cause short-term side effects like increased appetite and mood changes."
Dexamethasone is pronounced /dɛkˌsæməˈθoʊn/ in US English or /dɪkˌsæməˈθeɪstɒn/ in some UK/AU pronunciations. Break it into three parts: de-xa-me-tha-sone, with primary stress on the third syllable: dex-a-METH-a-one. Start with /dɛk/ (like deck), then /ˌsæm/ (sahm), then /ə/ (uh), then /ˈθoʊn/ or /ˈθeɪstɒn/ depending on accent. Keep the /θ/ as a dental fricative. A quick audio reference is available in medical pronunciation guides and YouGlish examples for “dexamethasone.”
Two common errors are: 1) misplacing stress on the second syllable (dex-a-METH-a-sone should have stress on the third). 2) mispronouncing the final -asone as -ass-one instead of -a-son e, and confusing /θoʊn/ with /θeɪstɒn/. Correct by pronouncing the final syllable clearly as /-hoʊn/ (US) or /-ɒn/ (UK/AU) and stressing the third syllable. Practice saying dex-uh-METH-uh-sohn slowly, then speed up while maintaining the rhythm.
In US, you’ll often hear /dɛkˌsæməˈθoʊn/, with a rhotic, clear /ɹ/ in contexts nearby, and final /oʊn/. UK/AU variants may render the last vowel as /ɒn/ or /əˈn/ depending on the speaker, with a non-rhotic pattern; some UK speakers pronounce the sequence as /ˈθeɪstən/ or /ˈθeɪsən/ in rapid speech. Pay attention to /θ/ articulation and the vowel quality of the stressed syllable (/oʊ/ vs /eɪ/).
The difficulty stems from two features: the sequence dex- (with a consonant cluster and the /k/ sound before /s/), and the mid-word placement of the /θ/ (theta) sound that requires precise dental articulation. The two-chunk rhythm (dex-a-METH-a- son e) plus the final /oʊn/ reduces predictability for non-medical speakers. Breaking it into syllables, stressing the third, and training the /θ/ with a light dental touch helps.
No standard form includes silent letters in typical pronunciation. The letters map to sounds: d-e-x-a-m-e-t-h-a-s-o-n-e; every letter corresponds to a sound in normalized pronunciation. The challenge is not silent letters but sequence and phoneme choices (e.g., /θ/ as a dental fricative, /oʊ/ vs /eɪ/ in the final vowel). When in rapid clinical speech, some vowels may reduced slightly, but the core sounds remain audible to professional listeners.
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Dexamethasone derives from the dexamethyl group (dex- meaning right-handed, a structural descriptor in stereochemistry) combined with the glucocorticoid steroid family. The suffix -asone signals a corticosteroid ketone structure. The term unfolds from systematic naming of corticosteroids in the early to mid-20th century, paralleling advances in synthetic steroid chemistry. The root dex- indicates a specific methylated configuration at a position on the steroid nucleus, while -methasone is a traditional naming syllable tied to methyl group substitutions that influence pharmacodynamics. First used in the scientific literature in the 1950s and 1960s as synthetic glucocorticoids were developed for medical therapies, dexamethasone became prominent due to its potent anti-inflammatory properties and favorable pharmacokinetics. In contemporary usage, it is a standard term across pharmacology, clinical medicine, and oncology, appearing in prescribing information, research articles, and medical education materials. The evolution of the term mirrors the broader history of corticosteroid synthesis—from natural hormones to highly potent synthetic analogs—while retaining the characteristic -asone ending that marks steroidal corticotherapy nomenclature.
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Words that rhyme with "Dexamethasone"
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