8 syllables: Sys, tem, ic Lu, pus Ery, the, ma, to, sus. Stress on tem.
sis-tem-ik-loo-puh-ser-ith-em-uh-TOH-suhs
/sɪˈstɛmɪk ˈluːpəs ˌɛrɪˌθɛməˈtoʊsəs/
Systemic Lupus Erythematosus is pronounced sis-tem-ik-loo-puh-ser-ith-em-uh-TOH-suhs (/sɪˈstɛmɪk ˈluːpəs ˌɛrɪˌθɛməˈtoʊsəs/). It has eight syllables (Sys-tem-ic Lu-pus Ery-the-ma-to-sus), with the stress on "tem". Systemic Lupus Erythematosus is a chronic autoimmune disease where the body's immune system attacks multiple organs and tissues. It manifests with diverse symptoms, including inflammation and fatigue, and can affect skin, joints, kidneys, and the cardiovascular system. The term combines systemic (throughout the body) with lupus erythematosus (the specific autoimmune syndrome).
nounSystemic Lupus Erythematosus is a chronic autoimmune disease where the body's immune system attacks multiple organs and tissues. It manifests with diverse symptoms, including inflammation and fatigue, and can affect skin, joints, kidneys, and the cardiovascular system. The term combines systemic (throughout the body) with lupus erythematosus (the specific autoimmune syndrome).
"Her rheumatologist diagnosed her with systemic lupus erythematosus after months of joint pain and fatigue."
"The patient’s care plan addresses renal involvement in systemic lupus erythematosus and monitors kidney function."
"Systemic lupus erythematosus can present with a butterfly rash across the cheeks and nose."
Pronounce as /sɪˈstɛm.ɪk ˈluː.pəs ˌɜː.θɪˌmeɪ.tɒˌsjuːs/ (US) or /sɪˈstɛm.ɪk ˈluː.pəs ˌɜː.θɪˌmeɪ.tɒ.sjuːz/ (UK). Stress falls on the first syllable of systemic and on lupus, with erythematosus carrying the secondary stress toward the end. Make a clear separation: sys-TEH-mic LOO-puss eh-ry-thee-MA-tuh-sus. Use a light, even rhythm between components and emphasize the patient-facing ‘lupus’ to avoid blending. Audio reference: a careful Google or YouTube pronunciation of “systemic lupus erythematosus” will align with IPA guidance.
Common errors include misplacing stress on systemic (treating it as SI-stem-ik) and muffling the ‘p’ in lupus (luh-PUS instead of LOO-pus). Another frequent slip is running eryth...met? no: erythematosus as eh-RE-thee-MAY-toh-sus or mispronouncing ‘θ’ as ‘s’. Correct by using the IPA forms: systemic /sɪˈstɛmɪk/; lupus /ˈluː.pəs/; erythematosus /ˌɜːr.ðiˈmeɪ.təˌsjuːs/ (AC: /ˌɪr ðə-?/ US: /ˌɜːr.θəˈmeɪ.tə.sjuːs/). Emphasize lupus and erythematosus, not the sentence cadence.
In US English, stress pattern is Systemic (secondary on ery-the-mat-o-sus) and rhotic R is pronounced. UK tends to non-rhoticity; the final -s of erythematosus is weaker; vowels in lupus are longer. Australian typically mirrors UK vowel quality but with more pronounced /ɹ/? AU often retains rhoticity in careful speech but may reduce some vowels. IPA references: US /sɪˈstɛmɪk ˈluːpəs ˌɜːθɪˈmeɪ.təˌsjuːs/, UK /sɪˈstɛmɪk ˈluːpəs ˌɜː.θɪˌmeɪ.tɒ.sjuːz/, AU /sɪˈstɛmɪk ˈluːpəs ˌɜːˈθɪˌmeɪ.tɒ.sjuːz/.
It's a long, multisyllabic medical term with three distinct morphemes and several consonant clusters. The 'systemic' prefix has a tricky /st/ cluster and a reduced /ɪ/ in the middle; lupus places strong initial stress on LOO-, and erythematosus includes a tricky 'th' or /θ/ in US and an -sjuːs ending. Students often smear the syllables or misplace the primary stress; practice with segmental isolation helps.
Some speakers wonder if the phrase has silent letters. In systemic lupus erythematosus, there are no silent letters; all components bear phonemic content. The emphasis and crisp enunciation are more important than silent-letters concern. Focus on the correct /ɜːr/ or /ɜː/ for erythematosus and on the /sjuːs/ ending to maintain precise pronunciation.
🗣️ Voice search tip: These questions are optimized for voice search. Try asking your voice assistant any of these questions about "Systemic Lupus Erythematosus"!
Systemic lupus erythematosus derives from Latin-based medical terminology. Systemic comes from late Latin systematis, from Greek systēma ‘an organized whole, whole housing’ with the sense of affecting the entire body. Lupus originates from Latin for ‘wolf,’ historically used in medicine to describe erosive skin lesions resembling a wolf bite; the term was adopted in the 19th century to describe chronic inflammatory skin and organ disease features. Erythematosus comes from Greek erythema ‘reddening,’ with -osis indicating a pathological condition. The combination reflects a whole-body autoimmune syndrome characterized by inflammation and tissue damage. First known uses appear in medical textbooks of the 19th and early 20th centuries, with systematic descriptions solidifying in rheumatology literature as diagnostic criteria evolved. Over time, the term stabilized as a standard descriptor for the multisystem autoimmune disorder we now know as systemic lupus erythematosus (SLE).
💡 Etymology tip: Understanding word origins can help you remember pronunciation patterns and recognize related words in the same language family.
Help others use "Systemic Lupus Erythematosus" correctly by contributing grammar tips, common mistakes, and context guidance.
💡 These words have similar meanings to "Systemic Lupus Erythematosus" and can often be used interchangeably.
🔄 These words have opposite meanings to "Systemic Lupus Erythematosus" and show contrast in usage.
📚 Vocabulary tip: Learning synonyms and antonyms helps you understand nuanced differences in meaning and improves your word choice in speaking and writing.
Words that rhyme with "Systemic Lupus Erythematosus"
-cus sounds
Practice with these rhyming pairs to improve your pronunciation consistency:
🎵 Rhyme tip: Practicing with rhyming words helps you master similar sound patterns and improves your overall pronunciation accuracy.
