5 syllables: Spi, ro, no, lac, tone. Stress on lac.
spir-oh-nuh-LAK-tohn
/ˌspɪroʊnəˈlæktoʊn/
Spironolactone is pronounced spir-oh-nuh-LAK-tohn (/ˌspɪroʊnəˈlæktoʊn/). It has five syllables (Spi-ro-no-lac-tone), with the stress on "lac". Spironolactone is a noun referring to a synthetic steroid medication that acts as a mineralocorticoid receptor antagonist and aldosterone antagonist. It is primarily used as a diuretic and in the treatment of conditions such as hypertension, edema, heart failure, and hormonal acne, as well as certain endocrine disorders. In medical contexts, it may be discussed in relation to electrolyte management (notably potassium handling), renal function, and its antiandrogenic effects, which can be relevant for conditions like polycystic ovary syndrome. Pronunciation is important in clinical communication to avoid misinterpretation with similar-sounding pharmaceutical terms. The word is often heard in medical lectures, patient consultations, and pharmaceutical research discussions. When speaking, you’ll likely encounter this term in compound lists or when prescribing, discussing indications, contraindications, and potential side effects. As a specialized term, it tends to appear in expert or professional contexts, though it is also encountered in patient education materials. The pronunciation should clearly convey the sequence of syllables to minimize confusion with other diuretic or steroid drugs.
nounSpironolactone is a noun referring to a synthetic steroid medication that acts as a mineralocorticoid receptor antagonist and aldosterone antagonist. It is primarily used as a diuretic and in the treatment of conditions such as hypertension, edema, heart failure, and hormonal acne, as well as certain endocrine disorders. In medical contexts, it may be discussed in relation to electrolyte management (notably potassium handling), renal function, and its antiandrogenic effects, which can be relevant for conditions like polycystic ovary syndrome. Pronunciation is important in clinical communication to avoid misinterpretation with similar-sounding pharmaceutical terms. The word is often heard in medical lectures, patient consultations, and pharmaceutical research discussions. When speaking, you’ll likely encounter this term in compound lists or when prescribing, discussing indications, contraindications, and potential side effects. As a specialized term, it tends to appear in expert or professional contexts, though it is also encountered in patient education materials. The pronunciation should clearly convey the sequence of syllables to minimize confusion with other diuretic or steroid drugs.
Common pronunciation errors (400-600 words): • Misplacing stress on the wrong syllable; you should stress the 'la' in 'lactone' as in spir-o-no-LAC-tone. • Slurring the 'no' into 'lo' or 'no' sounds; keep the middle vowels distinct: 'spi-ro-no-LA-ctone' rather than 'spi-ro-NO-la-kTON'. • Mispronouncing 'lactone' as 'lac-tone' or 'lak-tone' without clearly enunciating the 't' and 'one' ending; ensure you pronounce 'lac-tone' with a crisp 't' and the 'one' as /oʊn/. • Conflating with similar diuretics; practice the full word to avoid confusion with furosemide or hydrochlorothiazide syllables. Correction tips: slow the pace on the stressed syllable, exaggerate the 'la' in 'lactone' to set the correct rhythm, and pause briefly after the first three syllables to maintain clarity. Practice by breaking the word into four segments: spi- ro- no- lactone, pronouncing each segment clearly before blending. Repeat in sentences to build automatic pronunciation under clinical discussion timing. Use minimal pairs to contrast with other drug names that share the '-tone' suffix.
"The physician prescribed spironolactone to manage the patient’s hypertension and edema."
"In the clinical trial, spironolactone showed favorable effects on potassium balance in certain subjects."
"A dermatologist may consider spironolactone as part of a hormonal regimen for acne in select patients."
The word "Spironolactone" is pronounced /ˌspɪroʊnoʊˈlækˌtoʊn/ with emphasis on the primary stressed syllable. Click the audio button above to hear the correct pronunciation.
"Spironolactone" sounds like S-p-i-r-o-n-o-l-a-c-t-o-n-e. The pronunciation follows standard English pronunciation rules.
"Spironolactone" is considered expert difficult to pronounce. With practice and attention to the audio examples, you can master this pronunciation.
"Spironolactone" is a noun. It refers to a person, place, thing, or concept.
The International Phonetic Alphabet (IPA) transcription for "Spironolactone" is /ˌspɪroʊnoʊˈlækˌtoʊn/. This provides the most accurate pronunciation guide using standardized phonetic symbols.
Common mistakes when pronouncing "Spironolactone" include incorrect stress placement and mispronouncing vowel sounds. Listen to the audio example above to learn the correct pronunciation.
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Accent-specific guidance (400-600 words): • US: You’ll often hear the four-syllable pattern with primary stress on 'la' (spi-RO- no- LA- ctone). Emphasize the vowel clarity in 'spi' and 'no' and keep the final 'tone' with a clean /toʊn/. • UK: Similar rhythm, but you may notice slightly shorter vowels in fast speech; maintain the four clear syllables and ensure the 'lactone' portion is not merged. • Australian: Generally similar to US, but Australians may reduce unstressed vowels slightly; focus on maintaining the /spi-ɹo-ˈnɒləktəʊn/ cadence and ensure the 'lactone' ending is audible. Reference IPA in practice: /ˌspɪroʊˈnɒləktəʊn/ for UK-style, with attention to /ɒ/ vs /ɒ/ variant depending on speaker. Key contrasts include avoiding conflation with 'spironol' vs 'spironolacone' sounding mistakes; keep the 'lactone' closed with a crisp /t/. Use sentence-level practice: 'The doctor prescribed spironolactone for edema' to feel the natural rhythm in connected speech. • General tip: keep the 'ro' light, don’t overemphasize it, and deliver the 'la' with a decisive nucleus to anchor the word.
Spironolactone derives from combining two Greek-root-inspired constructs: 'spir-' likely draws on ‘spir’ from 'spira' meaning coil or spiral, though in pharmacology it is not a direct linguistic stem; more constructively, the name reflects its steroid-like core and ring structure typical of steroidal antimineralocorticoids. The suffix '-olactone' indicates a lactone ring, a cyclic ester, common in steroidal compounds. The 'spir-' portion may be associated with its distinctive spiral synthesis history, while the 'olactone' ending aligns with chemical nomenclature for lactone-containing steroids. The term first entered medical literature in the 1950s as researchers characterized its diuretic and antiandrogenic properties, later establishing its uses in edema, hypertension, and dermatologic conditions. Its development was tied to efforts to create potassium-sparing diuretics with additional hormonal effects. The combination of steroidal scaffold and lactone functionality led to the recognizable pharmacological class and the modern usage across multiple clinical specialties.
💡 Etymology tip: Understanding word origins can help you remember pronunciation patterns and recognize related words in the same language family.
Help others use "Spironolactone" correctly by contributing grammar tips, common mistakes, and context guidance.
💡 These words have similar meanings to "Spironolactone" and can often be used interchangeably.
🔄 These words have opposite meanings to "Spironolactone" and show contrast in usage.
📚 Vocabulary tip: Learning synonyms and antonyms helps you understand nuanced differences in meaning and improves your word choice in speaking and writing.
Words that rhyme with "Spironolactone"
-ion sounds
Practice with these rhyming pairs to improve your pronunciation consistency:
🎵 Rhyme tip: Practicing with rhyming words helps you master similar sound patterns and improves your overall pronunciation accuracy.
Comprehensive pronunciation guide (600-800 words): Introduction: Mastering spironolactone with confidence begins with recognizing its four-syllable structure and the need for clear articulation in clinical communication. Phonetic Profile and Core Challenges: The word comprises spi-ro-no-la-ctone with primary stress on the 'la' syllable in many pronunciations. Core challenges include maintaining distinct vowel qualities in 'spi' and 'ro', ensuring the 'la' nucleus is prominent, and delivering the final 'ctone' with a crisp /t/ and ending /oʊn/. Accent-Variations: In US, UK, and Australian accents, the rhythm is similar, but vowel quality may shift slightly (e.g., /ɒ/ vs /ɑ:/ or /oʊ/ vs /əʊ/). Understanding these subtle distinctions helps you sound natural across contexts. Advanced Practice Techniques: Use shadowing with medical narration, practice minimal pairs that differ in syllable emphasis, and perform rhythm drills to equalize syllable timing. Common Pitfalls: Avoid slurring 'la-ctone' into a single syllable, and avoid dropping the 't' in 'lactone'. Daily Integration: Use the word in patient-facing explanations, case notes, and pharmacology discussions to strengthen both pronunciation and familiarity. You’ll hear colleagues correctly identify spironolactone, and patients will benefit from clear communication about this therapy. This master guide emphasizes deliberate practice, consistent feedback, and contextual usage to achieve expert-level pronunciation proficiency with this pharmacological term.
