4 syllables: Sphin, go, lip, ids. Stress on lip.
sfing-goh-LIP-idz
/sfɪŋɡoʊˈlɪpɪdz/
Sphingolipids is pronounced sfing-goh-LIP-idz (/sfɪŋɡoʊˈlɪpɪdz/). It has four syllables (Sphin-go-lip-ids), with the stress on "lip". Sphingolipids are a class of lipids containing a sphingoid base backbone, typically with an amide-linked fatty acid and a head group. They play key roles in cell membranes and signaling. This term is used in biochemistry, neurobiology, and medical literature, and is pronounced with emphasis on the second syllable and a multisyllabic structure that can challenge English learners.
nounSphingolipids are a class of lipids containing a sphingoid base backbone, typically with an amide-linked fatty acid and a head group. They play key roles in cell membranes and signaling. This term is used in biochemistry, neurobiology, and medical literature, and is pronounced with emphasis on the second syllable and a multisyllabic structure that can challenge English learners.
"The neuron membranes are rich in sphingolipids, which contribute to membrane organization."
"Sphingolipids participate in signaling pathways related to apoptosis and inflammation."
"Researchers study sphingolipids to understand disorders like Niemann-Pick disease."
Break it as sfing-o-LIP-ids. Primary stress on LIP (third syllable). IPA: US /ˌsfɪŋɡoʊˈlɪpɪdz/, UK /ˌsfɪŋɡəˈlɪpɪdz/, AU /ˌsfɪŋɡəˈlɪpɪdz/. Start with sf- as in sphinx without the th, then -ing-; the i in lip sounds like 'lip', not 'leep'. Try to keep the /ŋɡ/ cluster tight: /ŋɡ/ immediately before /oʊ/.
Two main pitfalls: misplacing the stress (sphin-GO-li-pids vs sf-ING-o-li-pids) and mispronouncing the /ŋɡ/ cluster as separate syllables. Also the vowel quality in the second syllable often becomes /ə/ or /oʊ/ depending on speaker. Correction: emphasize the second half of the word: /ˌsfɪŋɡoʊˈlɪpɪdz/ (US) and keep the /ŋɡ/ together before the /oʊ/.
US: /ˌsfɪŋɡoʊˈlɪpɪdz/ with rhotic Rless base and /oʊ/. UK: /ˌsfɪŋɡəˈlɪpɪdz/ where the second vowel is a schwa /ə/ and non-rhotic. AU: similar to UK but with more centralized vowel qualities; some speakers use /sfɪŋɡəˈlɪpɪdz/ or /ˌsfɪŋɡəˈlɪpɪdz/ depending on individual variation.
It combines a rare lingual sequence /sfɪŋɡ/ with a long multisyllabic tail. The /ŋɡ/ cluster can be tricky, and the secondary stress placement on -lip- can be mis-set if speakers anticipate the ending. Practice by chunking: sfing-o | lip-ids, and ensure the /oʊ/ emerges clearly before lip.
There is no silent letter in sphingolipids. Every letter contributes to the normal pronunciation: the 'ph' is pronounced as /f/, the 'g' participates in the /ŋɡ/ cluster, and 'lid' ends with /dz/. Emphasize syllables: sfing-o- Li-pids, with the primary stress on lip.
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Sphingolipids derives from sphingosine, the foundational long-chain amino alcohol first identified in 1884 by Johann L. Thudichum? (note: sphingosine named after Spongia sphinx? actually from sphingosine, named after the Sphingidae? The etymology centers on sphingosine from sphingos, Greek for bind or squeeze, reflecting the molecule’s linkage to sphingolipids. The term sphingolipid combines sphingo- (from sphingosine) with lipid, denoting lipid molecules containing the sphingoid base. The word sphingo- originates from Greek sphingos meaning “span” or “bind,” but in biochemistry it’s used to denote the sphingoid backbone. The first use of sphingolipid chemistry in the modern sense arises in mid-20th century biochemistry as researchers identified sphingolipids in myelin and membranes, with early foundational work by Goldstein and others on sphingolipids and sphingomyelin in the 1940s–1960s. The term became standardized in the 1960s as lipid biochemists grouped these molecules into a distinct class, differentiating them from glycerophospholipids and other lipids. Over decades, the understanding of their roles in signaling, membrane microdomains, and disease has cemented sphingolipids as a central lipid class in biochemistry and medicine.
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Words that rhyme with "Sphingolipids"
-tis sounds
-ids sounds
Practice with these rhyming pairs to improve your pronunciation consistency:
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