4 syllables: Py, ri, dox, ine. Stress on dox.
pir-id-AHK-sin
/ˌpɪɹɪˈdɑksɪn/
Pyridoxine is pronounced pir-id-AHK-sin (/ˌpɪɹɪˈdɑksɪn/). It has four syllables (Py-ri-dox-ine), with the stress on "dox". Pyridoxine is a water-soluble vitamin B6, essential for amino acid metabolism, neurotransmitter synthesis, and red blood cell production. It functions as a coenzyme in various enzymatic reactions, contributing to energy production and nervous system health. In clinical contexts, pyridoxine is discussed regarding deficiency treatment and as part of vitamin B6 intake guidelines.
nounPyridoxine is a water-soluble vitamin B6, essential for amino acid metabolism, neurotransmitter synthesis, and red blood cell production. It functions as a coenzyme in various enzymatic reactions, contributing to energy production and nervous system health. In clinical contexts, pyridoxine is discussed regarding deficiency treatment and as part of vitamin B6 intake guidelines.
"Pyridoxine supplements are often recommended for certain deficiencies."
"Her symptoms improved after increasing pyridoxine intake under medical supervision."
"The nutrition label indicated a daily value of pyridoxine for adults."
Pyridoxine is pronounced as /ˌpaɪ.rɪˈdɒk.siːn/ in US and /ˌpaɪ.rɪˈdɒk.siːn/ in UK, with the primary stress on the third syllable: PY-ri-DOK-sine. Start with PY as /paɪ/, then RĪ- is reduced to /rɪ/ in rapid speech, then DOK as /ˈdɒk/ and finally sine as /siːn/. Note the long
Common errors include stressing the wrong syllable (placing stress on the 2nd or 4th instead of the 3rd), mispronouncing the 'dox' as /dəks/ rather than /dɒk/ and confusing the final '-ine' as /ɪn/ instead of /siːn. To correct: pronounce the stress on the 3rd syllable, keep 'dox' as /dɒk/ (not /dəks/), and finish with a long 'ee-n' sound /siːn/ rather than a short /ɪn/.
In US: /ˌpaɪ.rɪˈdɒk.siːn/ with rhotic r and a tense, long 'i' in 'sine'. In UK: /ˌpaɪ.rɪˈdɒk.siːn/ similar, non-rhotic influence is minor in careful speech; vowels may be slightly shorter. In Australian: /ˌpaɪ.rɪˈdɒk.siːn/ with broader vowel quality and a more clipped second syllable; keep the final /siːn/. Across all, the primary stress on the third syllable remains stable; the key variation is vowel quality and rhythm.
The difficulty lies in the multi-syllable structure and the 'dox' cluster leading into 'ine', plus the long 'i' in the final syllable. The sequence /rɪ dɒk/ requires a relaxed but precise tongue position. Emphasizing the third syllable without diluting the 'dox' cluster helps maintain accuracy in rapid speech. Practicing the word in isolation and in context will reduce hesitation and improve fluency.
No letters are truly silent in standard English pronunciation for pyridoxine. Each component syllable contributes its sounds: PY- (/paɪ/), ri (/rɪ/), dox (/dɒk/), ine (/siːn/). The potential challenge is maintaining the /siːn/ ending (not /sn/ or /sin/). Ensuring the final 'e' is long /iː/ makes the word sound complete rather than truncating the ending.
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Pyridoxine originates from the name of the pyridine ring system present in the molecule combined with the suffix -xine, reflecting older naming conventions for vitamins and nitrogen-containing compounds. The term pyridoxine is constructed from pyridine (the aromatic heterocycle) + -ox- (relating to oxygen-containing groups in the structure) + -ine (a common vitamin suffix). The modern vitamin B6 group includes pyridoxine, pyridoxal, and pyridoxamine, which share a common pyridine backbone. The word entered scientific usage in the mid-20th century as chemists isolated and characterized water-soluble forms of B6 and established nomenclature for vitamin-active compounds. First documented usage appears in biochemical literature around the 1930s–1950s, with broader clinical adoption as the vitamin’s essential role became clear in metabolic processes and deficiency mitigation. The term has since become standard in nutrition science, pharmacology, and clinical practice, particularly in discussions of supplementation and deficiency treatment.
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Words that rhyme with "Pyridoxine"
-ine sounds
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