4 syllables: Pro, cai, na, mide. Stress on cai.
proh-KAY-nuh-meyed
/pɹoʊˈkeɪnəmaɪd/
Procainamide is pronounced proh-KAY-nuh-meyed (/pɹoʊˈkeɪnəmaɪd/). It has four syllables (Pro-cai-na-mide), with the stress on "cai". Procainamide is a medicinal compound used to treat certain types of irregular heartbeats by stabilizing electrical impulses in the heart. It belongs to the class of antiarrhythmic drugs and is typically administered under medical supervision. The term combines a chemical prefix, procain- (from the amino- or anilide family), with the -amide suffix denoting an amide compound.
nounProcainamide is a medicinal compound used to treat certain types of irregular heartbeats by stabilizing electrical impulses in the heart. It belongs to the class of antiarrhythmic drugs and is typically administered under medical supervision. The term combines a chemical prefix, procain- (from the amino- or anilide family), with the -amide suffix denoting an amide compound.
"Procainamide was administered intravenously during the emergency monitor to control ventricular arrhythmia."
"The clinician discussed procainamide as an alternative when lidocaine was ineffective."
"Because procainamide can affect conduction, they monitored the patient with continuous ECG."
Pronounce as pro-KY-nah-mide with four syllables and the main stress on the second syllable: pro-KY-nah-mide. IPA guidance: US/UK often ˌproʊˈkaɪ.nəˌmaɪd; place stress on the second syllable, with secondary stress on the fourth: pro-KY-nə-MIDE. Tip: keep the /kaɪ/ diphthong tight, and end with /maɪd/. Listening reference: [audio in medical pronunciation resources].
Common errors include stressing the first or third syllable (pro-CAI-na-mide instead of pro-KY-na-mide) and mispronouncing the /kaɪ/ as /keɪ/ (pro-KEE-nə-mide). Another frequent slip is reducing the final /maɪd/ to /mide/ or /maɪt/. To correct: emphasize /kaɪ/ as a tight diphthong, keep /ə/ in the second syllable light, and clearly articulate the final /aɪd/ with a full glide into /d/.
In US, UK, and AU, the main difference is vowel quality and rhoticity; US tends to have a rhotic /ɹ/ with slightly longer /oʊ/ on the first syllable, while UK and AU reduce some rhotic coloring and use a more schwa-like second syllable. The /kaɪ/ stays stable, and final /maɪd/ is similar across regions, butAU speakers may produce a slightly broader /ɔɪ/ transition in some speakers. Overall the second syllable carries the primary stress in all accents.
It combines a complex consonant cluster and a long, multi-syllabic structure: pro-CAI-namide with a secondary stress pattern and the /kaɪ/ diphthong that can be mispronounced as /keɪ/. The final -mide resembles other drug names but differs in vowel length and articulation. The combination of medical-technical vocabulary and four syllables makes accurate articulation require careful tongue position for /kaɪ/ and a crisp /d/ ending.
Does procainamide have a silent letter in standard pronunciation? No. All letters contribute to syllables pro/ca/i/na/mide; there is no silent letter. The challenge is accurately merging the /kaɪ/ and the final /maɪd/, ensuring the /ɪ/ vowel before /d/ is not reduced. You’ll want a clear /na/ before the /m/.
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Procainamide derives from chemical nomenclature. The prefix 'pro-' can indicate 'in front of' or a driving prefix in naming, while 'caine' is a suffix linked to local anesthetics in some drug classes but here is part of the amide family. The root 'procain-' reflects the structure related to para-aminobenzoic derivatives used in chemistry for synthesis of amide compounds. The term was adopted in pharmacology to designate a specific amide-type antiarrhythmic, with first known references appearing in the mid-20th century as researchers classified antiarrhythmic agents by their ion channel interactions. The evolution of its use followed the broader development of class I and III antiarrhythmics, and the name became standardized in medical language as procainamide, differentiating from other amis in clinical naming conventions, while retaining its root in the amide chemistry tradition and the pharmacological history of arrhythmia management.
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Words that rhyme with "Procainamide"
-ide sounds
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