4 syllables: Mo, sa, ic, ism. Stress on sa.
moh-ZAY-ziz-uhm
/moʊˈzeɪzɪzəm/
Mosaicism is pronounced moh-ZAY-ziz-uhm (/moʊˈzeɪzɪzəm/). It has four syllables (Mo-sa-ic-ism), with the stress on "sa". Mosaicism is a genetic condition where two or more genetically distinct cell lines exist within one individual, arising from mutations after fertilization. It can affect various tissues and may result in partial or tissue-specific expression of traits. The term is used in medical genetics and pathology contexts to describe this cellular mosaic distribution.
nounMosaicism is a genetic condition where two or more genetically distinct cell lines exist within one individual, arising from mutations after fertilization. It can affect various tissues and may result in partial or tissue-specific expression of traits. The term is used in medical genetics and pathology contexts to describe this cellular mosaic distribution.
"The patient was diagnosed with somatic mosaicism, explaining the patchy skin lesions despite an overall healthy appearance."
"Germline mosaicism can complicate inheritance patterns, as some sperm or eggs carry a mutation while others do not."
"Researchers study mosaicism to understand how cells with different genotypes coexist within the same organism."
Mosaicism is pronounced ma-ˈzɔɪ-ɪ-zəm in broad terms, with the primary stress on the second syllable: ma-ZO-i-sism. IPA: US /ˌmoʊˈzeɪ.ɪˌzɪzəm/ or /ˌmoʊˈzeɪ.ɪ.zɪzəm/; UK /ˌməʊˈzeɪ.ɪˌzɪz(ə)m/; AU /ˌmæˈzeɪ.ɪ.zəm/. Avg speaker rhythm emphasizes the diphthong in the second syllable and a clear unstressed final -zəm.
Common errors include misplacing the stress (saying ma-zo-IS-m or ma-zoy-IS-m) and flattening the second syllable’s diphthong. To correct, keep primary stress on the second syllable: ma-ZO-i-sism, and sharply articulate the /eɪ/ in the second syllable as a clear diphthong, not a short vowel. The final -zəm should be light and quick.
In US and UK accents, the second syllable carries primary stress, with a clear /eɪ/ in /zeɪ/. US speakers may reduce the final syllable slightly less than UK speakers. Australian pronunciation mirrors UK rhythms but often reduces the final schwa more. In all, the internal /z/ and /ɪ/ positions remain steady; the main variance is vowel quality and final syllable reduction.
Because it combines a mid-stress diphthong with a post-syllabic /zɪz/ cluster and a final unstressed /əm/. The /ə/ in -ism can be weak, leading to a tensed or clipped ending. Focus on keeping the /zeɪ/ in the second syllable and enunciating the /z/ before the /ɪ/ clearly, then relax the final /əm/.
No, mosaicism is phonemically fully spoken; every letter participates in a sound. The challenge is the multi-syllabic rhythm and diphthong shaping: the /zeɪ/ diphthong and the sequence /ɪzəm/ require careful articulation rather than silent letters.
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Mosaicism derives from the word mosaic, which originates from the Latin mosaicus, from Greek mousa ‘muse’ and ikos ‘pertaining to’ through the notion of colored, variegated stone work. The broader concept of mosaic in biology and medicine uses the same image: distinct, colored tiles representing different cell populations within one body. The first recorded use in a genetic context is from the mid-20th century as cytogenetic techniques revealed patches of cells with different chromosomal makeups in a single individual. Over time, the term expanded to refer to any condition where two or more genetically distinct cell lineages exist in one organism, not necessarily tied to artful mosaic patterns. In modern genetics, mosaicism is characterized by post-zygotic mutations that create divergence in cell lineages, leading to patchy phenotypic distributions. The concept has clinical implications across dermatology, neurology, and prenatal diagnosis, and it is central to understanding variable expressivity and recurrence risk in families. The etymology thus mirrors the image of a mosaic artist’s palette: many colors in one work, each representing a separate genotype within a single biological canvas.
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Words that rhyme with "Mosaicism"
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