4 syllables: Mir, ta, za, pine. Stress on ta.
mur-TAZ-uh-peen
/mɝˈtæzəpiːn/
Mirtazapine is pronounced mur-TAZ-uh-peen (/mɝˈtæzəpiːn/). It has four syllables (Mir-ta-za-pine), with the stress on "ta". Mirtazapine is a tricyclic-like tetracyclic antidepressant used to treat major depressive disorder and other mood disorders. It works by altering neurotransmitter activity in the brain, producing daytime sedation or sleep effects depending on dosage. The term is a medical noun, often encountered in clinical and pharmacological contexts.
nounMirtazapine is a tricyclic-like tetracyclic antidepressant used to treat major depressive disorder and other mood disorders. It works by altering neurotransmitter activity in the brain, producing daytime sedation or sleep effects depending on dosage. The term is a medical noun, often encountered in clinical and pharmacological contexts.
"The patient was prescribed mirtazapine after inadequate response to SSRI treatment."
"In some patients, mirtazapine can cause drowsiness and weight gain as common side effects."
"The clinician discussed mirtazapine’s mechanism of action and potential interactions."
US/UK/AU pronunciation centers on mi-rtah-ZAY-pin, with stress on the third syllable: mɜːr-təˈzeɪ-pin (US), məˈtæzəˌpeɪn in some variants; ensure the final -pine rhymes with 'sign' or 'line' depending on accent. IPA: US ɜːrˈtæzəˌpeɪn; UK məˈtæzəˌpeɪn; AU mē-tā- zat- pen. Listen to a clinical recording or Forvo for precise regional tonality.
Common errors: misplacing stress (treating it as mir-TAZ-a-pine instead of mir-ta-ZA-pine); mispronouncing the -ta- as ‘tah’ rather than a schwa; dropping or altering the final -pine vowel (saying -peen instead of -pain). Corrections: emphasize the second-to-last stress on -ze- or -za depending on region, keep the -ta- unstressed as a weak mushed vowel, and end with a clear -pin like ‘pin’ but with a lighter vowel than ‘peen’. IPA cues: US ɜːrˈtæzəˌpeɪn; UK məˈtæzəˌpeɪn.
US tends to reduce unstressed syllables and may use a rhotic vowel in the first syllable (ɜr), with strong emphasis on -za-. UK typically uses a clearer /ə/ in the first syllable and a non-rhotic r, with a crisp -peɪn ending. Australian tends toward a more centralized vowel in the first syllable and a longer /eɪ/ in -peɪn; mouth shape is wider for /æ/ in some speakers. IPA anchors: US ɜrˈtæzəˌpeɪn; UK məˈtæzəˌpeɪn; AU ˈmɜːtəˌzæpɪn.
The combination of multiple syllables with a mid- short vowel in the first two syllables, plus the -zap- cluster and the final -ine that can be realized as /peɪn/ or /pɪn/, creates phonetic ambiguity. The stress pattern is not always intuitive for non-medical speakers, and the 'rzə' sequence can elide in fast speech. The -ta- and -ze- consonant sequence demands precise tongue placement; practice with slow syllable-by-syllable enunciation to stabilize rhythm and reduce conflation with similar antidepressants.
The -z- in the middle and the 'apine' ending create a unique 'zəɪn' vs 'peɪn' realization depending on speaker. The diphthong in -zeɪ- can align with /eɪ/ as in 'fade' or sometimes more clipped as /zeɪ/. The combination of /t/ followed by /æ/ and /z/ before /ə/ adds a mild consonant cluster that can challenge learners used to simpler endings. Focus on the second syllable stress and the long -eɪ- sound toward the end.
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US: rhotic /ɜːr/ in the first syllable; some speakers flatten /ə/ to /ɚ/ in connected speech; pronounced /ˈmɜːrtəzeɪpeɪn/ with strong first syllable. UK: non-rhotic /ə/ and a crisper /z/ before /eɪ/; final stress on -zeɪ-; /ˈmɜːtəˌzeɪpeɪn/. AU: broader vowels; /ˈmɜːtəzˌpeɪn/ or /ˈmɜːtæzpeɪn/ depending on region; avoid over-emphasizing; maintain clear /z/. IPA references: US ɜːrˈtæzəˌpeɪn; UK məˈtæzəˌpeɪn; AU ˈmɜːtəˌzeɪpeɪn.
Mirtazapine is a synthesized antidepressant whose name is built from chemical naming conventions rather than everyday roots. The initial syllable mirt- is derived from the drug’s complex polycyclic structure and related naming conventions used in medicinal chemistry, but it does not correspond to a common dictionary root. The -azapine part places it among the class of heterocyclic antidepressants that include other azapine derivatives; ‘aza-’ indicates nitrogen substitution within a ring, while ‘pine’ echoes the family resemblance to other psychotropic agents like mirtazapine’s structural cousins. The term entered medical literature in the 1990s as the compound was developed and studied for pharmacologic effects, distinguishing itself from older tricyclics by its receptor profile and clinically observed sedation pattern. The exact first known use in published literature traces to early clinical trial reports and pharmacology reviews of the azapine subclass, with brand-named introductions later reinforcing the word’s adoption in prescribing language. Over time, the word shifted from strictly technical documentation to common clinical parlance as practitioners discussed its indications, dosing, and side-effect profile in patient care and guidelines.
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Words that rhyme with "Mirtazapine"
-ine sounds
Practice with these rhyming pairs to improve your pronunciation consistency:
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