4 syllables: Mi, cro, tub, ules. Stress on Mi.
MEYE-kroh-tyoo-byoolz
/ˈmaɪ.kroʊ.tjuː.bjuːlz/
Microtubules is pronounced MEYE-kroh-tyoo-byoolz (/ˈmaɪ.kroʊ.tjuː.bjuːlz/). It has four syllables (Mi-cro-tub-ules), with the stress on "Mi". Microtubules are long, hollow protein filaments that form part of the cytoskeleton in eukaryotic cells, helping shape cells, organize components, and enable intracellular transport and division. They’re composed of tubulin subunits arranged in a helical lattice, and they dynamically polymerize and depolymerize in response to cellular needs. This term is used in molecular biology, cell biology, and related research contexts.
nounMicrotubules are long, hollow protein filaments that form part of the cytoskeleton in eukaryotic cells, helping shape cells, organize components, and enable intracellular transport and division. They’re composed of tubulin subunits arranged in a helical lattice, and they dynamically polymerize and depolymerize in response to cellular needs. This term is used in molecular biology, cell biology, and related research contexts.
- You’ll often misplace the primary stress, saying mi-CRO-tub-ules or mi-kro-TU-bules. Fix by practicing the first syllable with strong force, then gently step into /ˌtjuː/ cluster. - The /tjuː/ cluster can morph into /tjʊ/ or /tju/; target a tight /tjʊ/ or /tjuː/ by sliding from /t/ to /j/ without an extra vowel. - Final -bules can slip into -byools; keep the /bjuːlz/ as a bilabial + yuː + lz sequence; avoid turning it into /bz/ or /bəlz/. - When saying rapidly, the middle vowels can reduce; practice with slow speed then build rhythm to maintain segment clarity. - Do a quick mouth check: lips rounded for /oʊ/ in kro, tongue high for /juː/; avoid dragging vowels into neighboring syllables.
"Researchers visualized microtubules using fluorescence microscopy to observe spindle dynamics during mitosis."
"The drug destabilizes microtubules, preventing proper chromosome separation."
"Motor proteins like kinesin walk along microtubules to transport vesicles."
Say MI-kro-TU-bules with stress on the first and third syllables in many contexts. IPA US: /ˈmaɪ.kroʊˌtjuːˌbjuːlz/; UK: /ˈmaɪ.krəʊˌtjuːˌbjuːlz/. The middle syllable can reduce to a schwa in rapid speech: /ˈmaɪ.kroʊˌtjuːˌbjuːlz/ or /ˈmaɪ.krəʊˌtjuːˌbjuːlz/. Focus on the “tjuː” cluster: avoid letting it become a separate “too” syllable; keep it as a tight glide from /t/ into /juː/.
Common errors: (1) misplacing stress (putting emphasis on the second or third syllable); (2) treating the /juː/ as two separate sounds like /j/ and /uː/ with an extra vowel; (3) mispronouncing /ˌtjuː/ as /tjʊ/ or /tjuː/ with an incorrect diphthong. Correction: keep /tjuː/ as a single light syllable after /ˈmaɪ.kroʊ/; ensure the /juː/ is a tight, rounded high back vowel, and avoid an extra syllable.
In US English, you’ll hear /ˈmaɪ.kroʊˌtjuːˌbjuːlz/ with a clear /oʊ/ in 'tro' and non-rhotic-ish linking; UK English often has a shorter /əʊ/ in the second syllable and a crisper /tj/ cluster: /ˈmaɪ.krəʊˌtjuːˌbjuːlz/. Australian tends toward a broader /ɜː/ in unstressed vowels and a slightly different rhythm: /ˈmaɪ.kroʊˌtjuːˌbjuːlz/ or /ˈmaɪ.kɹoːˌtjuːˌbjuːlz/. Core rhotics are less prominent in non-US varieties.
Difficulties stem from the /tjuː/ cluster after a strong first syllable and the long, multi-syllabic word with several consecutive vowels. The combination /ˌtjuːˌbjuː/ includes two high-front rounded vowels in close sequence, which can trip up non-native speakers. Focus on keeping the /t/ release tight, the /juː/ as a single glide, and the final /lz/ in a light, voiced stop transition.
A distinctive feature is the strong initial stress on MI-, followed by a staggered secondary emphasis on -tu- in fast scientific speech. The sequence /ˈmaɪ.kroʊˌtjuː/ requires maintaining a clear boundary between /kroʊ/ and /tjuː/, avoiding a fused or rushed middle. In careful speech, you’ll hear a crisp /ˈmaɪ.kroʊˌtjuːˌbjuːlz/ with the /tjuː/ clearly articulated as a unit rather than two separate sounds.
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- US: Strong rhotic influence; keep /ˈmaɪ/ as a bright diphthong, then /kroʊ/ with rounded /oʊ/ and a distinct /ˌtjuː/ cluster; ensure final /bjuːlz/ doesn’t reduce. - UK: Slightly more centralized vowel in /kroʊ/; /əʊ/ in /kroʊ/ tends toward /əʊ/; keep /ˈmaɪ.krəʊˌtjuːˌbjuːlz/ with crisper /k/ and /t/ separation. - AU: May have broader vowels; maintain /ˈmaɪ.kroːˌtjuːˌbjuːlz/ with a longer /oː/ or /oʊ/ depending on speaker; keep rhotics less pronounced; ensure the final cluster remains clear.
Micro- comes from Latin micro- meaning small. Microtubule derives from tubule (a small tube) from Latin tubulus, with the augmentative micro- prefix indicating very small. The combining form tubul- relates to tubes or pipe-like structures. The first widely cited use of the term microtubule appears in mid-20th-century cell biology literature as researchers began to describe tube-like cytoskeletal components that are larger than microfilaments but smaller than other organelles. Over time, the understanding of microtubules expanded to encompass their dynamic instability, polarity (plus and minus ends), and role in mitosis, intracellular transport, and maintenance of cell shape. The word reflects a composite of micro- (small) and tubule (tube), signaling both scale and tubular architecture. Modern usage often specifies assemblies composed of tubulin that polymerize into hollow, cylindrical polymers, critical for trafficking and chromosome movement. First known uses appear in biochemistry and histology texts from the 1960s–1970s as electron microscopy revealed microtubule structures and their functions in eukaryotic cells.
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Words that rhyme with "Microtubules"
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