4 syllables: Me, ty, ra, pone. Stress on ra.
met-ir-AP-ohn
/mɛtɪˈræpoʊn/
Metyrapone is pronounced met-ir-AP-ohn (/mɛtɪˈræpoʊn/). It has four syllables (Me-ty-ra-pone), with the stress on "ra". Metyrapone is a pharmaceutical agent used to inhibit adrenal steroid synthesis, often in diagnostic testing and research settings. It is a noun referring to this specific enzyme-blocking drug, typically discussed in medical or pharmacological contexts. The term itself is a compound name derived from chemical roots, pronounced as a multi-syllabic, high-precision term common in clinical literature.
nounMetyrapone is a pharmaceutical agent used to inhibit adrenal steroid synthesis, often in diagnostic testing and research settings. It is a noun referring to this specific enzyme-blocking drug, typically discussed in medical or pharmacological contexts. The term itself is a compound name derived from chemical roots, pronounced as a multi-syllabic, high-precision term common in clinical literature.
"The clinician requested a metyrapone challenge to assess the integrity of the pituitary-adrenal axis."
"Laboratory protocols specify metyrapone dosing and timing for accurate cortisol suppression."
"Researchers evaluated metyrapone’s effects on steroidogenesis in adrenal tissue cultures."
Metyrapone is pronounced met- YRA-pohn with primary stress on the second syllable. IPA: US ˌmɛtɪˈræpoʊn, UK ˌmɛtɪˈræpəʊn, AU ˌmɛtɪˈræpɒn. Start with 'met' as in 'metal' but shorter, then 'yra' as in 'rye-rah', and finish with 'pone' rhyming with 'own' (poʊn in US, poʊn/poʊn). Ensure the second syllable carries the loudest emphasis; the final syllable remains light but clear.
Common errors include stressing the first syllable (met-), turning the second syllable into a dull single syllable (met-yr-a-pon-e), or mispronouncing the final 'pone' as 'poon' instead of 'pone' (poʊn). Correct by placing primary stress on the second syllable (met-YRA-po(ne)) and making the final 'pone' rhyme with 'own' (poʊn). Practice with minimal pairs to feel the rhythm: met-YRA-po-n. IPA reminders: US ˌmɛtɪˈræpoʊn; UK ˌmɛtɪˈræpəʊn.
US rhythm leans to a slightly longer final 'pone' with clear 'poʊn' and a strong second-syllable stress. UK often reduces the final vowel slightly, so the last syllable can sound less pronounced while keeping the second syllable prominent; IPA for UK is ˌmɛtɪˈræpəʊn. Australian tends to vowel-consonant clarity with a crisp 'yra' and final 'pone' like 'pohn' (ˌmɛtɪˈræpɒn). Across all, the main stress remains on the second syllable.
The difficulty stems from a multi-syllable compound with a consonant cluster and a diphthong in the final syllable. The 'tyra' sequence places the nucleus between two consonants, demanding accurate articulation of /t/ + /ɪ/ + /ˈræ/ transitions. The final 'pone' 'poʊn' requires precise mouth shape for the tense vowel followed by a nasal. Position your tongue behind the upper teeth for the 't' and lift the tongue quickly to form the 'YRA' vowel cluster. Slower articulation helps anchor the rhythm.
Does the stress shift when saying 'Metyrapone' in rapid clinical dialogue versus a careful, isolated pronunciation? In careful speech, stress remains on the second syllable met-YRA-po-ne. In rapid or field notes, you may hear slight neutralization where the second syllable is still prominent but slightly less stressed, yet not shifting to the first or third syllable. Maintain IPA reference ˌmɛtɪˈræpoʊn across contexts.
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- US: emphasize the second syllable with a clear /æ/ in 'YRA'; rhoticity is preserved, so the /r/ is pronounced. - UK: maintain non-rhotic tendency; final syllable slightly less stressed; /əʊ/ in 'pone' becomes /əʊ/. - AU: crisp consonant enunciation; keep final /n/ clear; vowels slightly more centralized. IPA: US ˌmɛtɪˈræpoʊn, UK ˌmɛtɪˈræpəʊn, AU ˌmɛtɪˈræpɒn. Focus on the second syllable's vowel quality and rhotic vs non-rhotic influences.
Metyrapone derives from chemical nomenclature, combining elements that denote its mechanism and structure. The prefix 'met-' echoes methyl or methylene origins in organic chemistry, while '-tyra-' references specific ring or scaffold components common in mid- to late-20th-century synthetic drug naming. The suffix '-pone' is a traditional tying element seen in some drug names, though not indicative of a single functional group. The first documented uses appear in pharmacological literature from the 1960s–70s, where researchers described metyrapone’s ability to inhibit 11-beta-hydroxylase in the adrenocortical steroid synthesis pathway, enabling diagnostic and investigative applications. Over decades, the term has maintained stable pronunciation across international medical communities, with minor regional vowel shifts but consistent stress placement on the antepenultimate syllable (met-YRA-pone) in many English-speaking medical contexts. Early pharmacology texts emphasize its role in stress-testing the hypothalamic-pituitary-adrenal axis, and its nomenclature has remained tied to its chemical identity as a steroidogenesis inhibitor. Modern usage is largely confined to clinical and research domains, preserving the term as a specialized vocabulary item for experts and students alike.
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Words that rhyme with "Metyrapone"
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