3 syllables: Mac, ro, phage. Stress on Mac.
MAK-roh-fayj
/ˈmækɹoʊˌfeɪdʒ/
Macrophage is pronounced MAK-roh-fayj (/ˈmækɹoʊˌfeɪdʒ/). It has three syllables (Mac-ro-phage), with the stress on "Mac". Macrophage is a large immune cell that ingests and digests cellular debris, foreign particles, and pathogens. It develops from monocytes and plays a critical role in both innate and adaptive immunity, including antigen presentation and cytokine production. In biology, macrophages are found in nearly all tissues, acting as scavengers and orchestrators of inflammatory responses.
nounMacrophage is a large immune cell that ingests and digests cellular debris, foreign particles, and pathogens. It develops from monocytes and plays a critical role in both innate and adaptive immunity, including antigen presentation and cytokine production. In biology, macrophages are found in nearly all tissues, acting as scavengers and orchestrators of inflammatory responses.
"The macrophage engulfed the bacteria and initiated the inflammatory response."
"Researchers studied macrophage activation in response to the viral infection."
"Macrophages differentiate from monocytes in response to tissue injury."
Macrophage is pronounced mə-CROH-fayjh or /ˌmækrəˈfeɪdʒ/. Put primary stress on the third syllable: mac-ROH-face? Correctly, it’s mak-ruh-FAYJ with /feɪdʒ/ as in 'fadge' or 'badge' with a soft 'j' sound. Think: mauk-ruh-FAYJ. Audio references: you can check Cambridge/Oxford dictionaries’ pronunciations or Forvo for native samples.
Common errors include misplacing stress (saying macro-PHAGE) and mispronouncing the 'ph' as 'f' without the following 'age' ending, or swallowing the middle syllable. Correct it by stressing the 'feɪdʒ' end: mak-ruh-FAYJ, with a clear 'f' + 'ay' + 'j' blend. Ensure you articulate /ˈfeɪdʒ/ at the end and don’t reduce the middle syllable to a schwa.
Across US/UK/AU, the initial syllable /ˈmækrə-/ remains similar, but vowel quality can shift slightly: US tends to a broader /æ/ in 'mac,' UK often preserves a shorter schwa in the second syllable depending on speaker, while AU can be closer to /ˈmækrəˌfeɪdʒ/ with subtle vowel broadening in connected speech. The final /feɪdʒ/ is generally rhotic-neutral in non-rhotic accents. IPA remains /ˌmækrəˈfeɪdʒ/ across regions, with small allophonic differences.
Difficult because it combines uncommon syllable stress and a voiced palato-alveolar affricate /dʒ/ at the end, after /feɪ/. Many speakers misplace emphasis or flatten the /rə/ middle syllable. Focus on the end: /feɪdʒ/ and keep the middle syllable distinct as /rə/. Practice by isolating /mækrə/ and /feɪdʒ/ in sequence to strengthen the transition.
One unique nuance is maintaining a crisp /k/ onset in the 'mac' part and ensuring the 'phage' is not pronounced like 'phagy' but as /feɪdʒ/. Also, avoid reducing the middle 'rə' to a near-schwa in rapid speech; keep it light and short. Emphasize the final /feɪdʒ/ cluster clearly; it anchors the word’s sound and differentiates it from similar terms like macrophage-like words in immunology.
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Macrophage comes from micro- or macro- meaning 'large' (Greek macros) plus -phage from phagein meaning 'to eat' (Greek phagein). The term reflects the cell’s large size relative to other phagocytes and its eating function. The concept of macrophages emerged in the early 19th century as scientists distinguished larger scavenger cells from smaller leukocytes. The modern understanding tied macrophages to the mononuclear phagocyte system and antigen presentation, with the term solidifying in mid-20th-century immunology literature. First known usage in scientific context dates to the 1890s-1900s as researchers described large phagocytic cells in tissues, and by the 1960s-1970s, macrophages were central to innate immunity models, tissue remodeling, and pathology studies. The compound word fuses Greek roots for size and eating, aligning with the functional biology of these cells across species.
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💡 These words have similar meanings to "Macrophage" and can often be used interchangeably.
🔄 These words have opposite meanings to "Macrophage" and show contrast in usage.
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Words that rhyme with "Macrophage"
-age sounds
Practice with these rhyming pairs to improve your pronunciation consistency:
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