2 syllables: Ly, sis. Stress on Ly.
LEYE-sis
/ˈlaɪsɪs/
Lysis is pronounced LEYE-sis (/ˈlaɪsɪs/). It has two syllables (Ly-sis), with the stress on "Ly". Lysis is a noun in biology and medicine referring to the disintegration or dissolution of a cell, parasite, or other structure, typically due to rupture of the cell membrane or breakdown of its components. It describes a process where contents are released, often as part of viral life cycles, immune responses, or experimental conditions. The term is also used in chemistry to denote cleavage or breakdown reactions that separate a compound into smaller parts.
nounLysis is a noun in biology and medicine referring to the disintegration or dissolution of a cell, parasite, or other structure, typically due to rupture of the cell membrane or breakdown of its components. It describes a process where contents are released, often as part of viral life cycles, immune responses, or experimental conditions. The term is also used in chemistry to denote cleavage or breakdown reactions that separate a compound into smaller parts.
"During osmotic lysis, red blood cells burst and release hemoglobin."
"The drug induces lysis of bacterial biofilms, aiding treatment."
"Viral lysis releases viral particles from the host cell to propagate infection."
Lysis is pronounced LI-sis, with the primary stress on the first syllable. In IPA for US: /ˈlɪsɪs/; UK and AU commonly render it as /ˈlaɪsɪs/, especially in non-US contexts. Mouth position starts with a short, lax /ɪ/ sound as in sit for the first vowel in US, or a long glide /aɪ/ as in lie for UK/AU. Follow with a short /s/ and a final schwa-like /ɪs/.”
Common mistakes include pronouncing the first syllable as long /iː/ (LEE-sis) or misplacing the stressed vowel as /eɪ/ (LAY-sis). Another frequent error is delaying the final /s/ making it /z/ or adding an extra vowel sound in the second syllable. To correct: keep the first syllable short and unstressed in US /ˈlɪsɪs/, avoid vowel lengthening in rapid speech, and end with crisp /s/ rather than a voiced /z/.
In US English, lysis tends to /ˈlɪsɪs/, with a short first vowel and a rhotacized context affecting surrounding vowels less. In UK and AU, it commonly shifts to /ˈlaɪsɪs/, with a diphthong in the first syllable (lie). The main differences are vowel height and quality in the first syllable and the presence or absence of rhoticity effects in connected speech, though final /s/ remains voiceless. Expect slight regional variation in publication titles and scientific literature.
Lysis challenges include the two-syllable structure with a short /ɪ/ in US or a diphthong in UK/AU, and the crisp final /s/ that can be mispronounced as /z/ in rapid speech. The sequence /ˈlɪsɪs/ or /ˈlaɪsɪs/ demands precise tongue placement: high front lax /ɪ/ or high front glide /aɪ/ followed by a voiceless alveolar sibilant. In connected speech, the alveolar sibilant can soften before a consonant, so focus on holding the /s/ sound distinctly.
A unique aspect is the potential for vowel quality shift between ASL-like readings and scientific citations. Some speakers prefer a short, clipped /ɪ/ in the first syllable in clinical or lab settings, while others maintain a clear /aɪ/ in non-technical contexts. The key is consistency within a document: choose /ˈlɪsɪs/ or /ˈlaɪsɪs/ and maintain that pattern across usage. IPA reference and mouth positioning should be memorized for both variants.
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Lysis comes from the Greek lysis, meaning loosening, dissolution, or breaking apart, from lýsei(n) to loosen or dissolve, related to lyein to loosen. In ancient Greek, lysis referred to loosening and dissolution in medical contexts. The term entered Latin as lysis and was adopted into early modern science to describe cellular disintegration. In biology and medicine, the suffix -lysis appended to verbs and stems to indicate a process of breaking down (e.g., hemolysis, hydrolysis). First known use in English literature traces to 19th century scientific texts describing cellular processes, with rapid growth in microbiology and pathology in the 20th century as techniques allowed precise observation of cell rupture and lytic mechanisms. The word’s meaning has broadened from general “loosening” to a specific, technical mechanism that involves membrane disruption or enzymatic cleavage, often used in diagnostics, therapeutics, and research on immune and pathogenic processes.
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💡 These words have similar meanings to "Lysis" and can often be used interchangeably.
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Words that rhyme with "Lysis"
-sis sounds
Practice with these rhyming pairs to improve your pronunciation consistency:
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