4 syllables: Leu, ko, pe, nia. Stress on pe.
lyoo-kuh-PEE-nyuh
/ljuːkəˈpiːnjə/
Leukopenia is pronounced lyoo-kuh-PEE-nyuh (/ljuːkəˈpiːnjə/). It has four syllables (Leu-ko-pe-nia), with the stress on "pe". Leukopenia is a medical term describing an abnormally low white blood cell count. It’s a specialized noun used in clinical contexts and research, typically values below the normal range indicate susceptibility to infections. The word combines roots meaning white (leuko) and lack/deficiency (penia).
nounLeukopenia is a medical term describing an abnormally low white blood cell count. It’s a specialized noun used in clinical contexts and research, typically values below the normal range indicate susceptibility to infections. The word combines roots meaning white (leuko) and lack/deficiency (penia).
"The oncologist monitored leukopenia during high-dose chemotherapy."
"Chronic leukopenia requires further investigation to identify underlying causes."
"She experienced leukopenia after the bone marrow suppression episode."
Pronunciation: /ˌluːkəˈpiːniə/ (US) or /ˌljuːkəˈpiːniə/ (UK). Primary stress on the third syllable, leu-KO-pee-nee-uh; break as leu-ko-pe-nia. The initial ‘leuko’ sounds like ‘loo-koh’; the middle ‘pen’ sounds like ‘pee’ with -ia forming a light -yə ending. Practice by saying loo-koh-PEE-nee-uh with a smooth, not hiccuped flow. Audio reference in standard medical dictionaries can guide exact vowel lengths.
Two common errors: 1) stressing the wrong syllable, saying leu-KO-pe-NEE-uh; correct is leu-KO-pe-NEE-ə with primary stress on the third syllable. 2) mispronouncing the -nia as ‘nah’ or ‘nee-ah’ with wrong vowel. The accurate ending is a light -nee-ə, not a hard syllable. Focus on transitioning from ‘pee’ to a soft, unstressed ‘ni-a’ to preserve the medical cadence.
US: /ˌluːkəˈpiːniə/ with a clear long 'oo' in leuko and stress on pi: 'pee'. UK: /ˌljuːkəˈpiːniə/ may feature a slightly fuller front vowel in the initial syllable and non-rhotic final 'r'. AU: /ˌluːkəˈpiːniə/ similar to US but with subtle vowel clipping and vowel quality that may be slightly more centralized. Across accents, the main differences are vowel length and rhoticity (US/AU rhotic, UK non-rhotic).
It combines a clinical prefix (leuko-), a tense middle syllable, and an unfamiliar -penia ending. The trill of 'ko' in the middle can force the mouth into a tight position, and many learners misplace stress on the prefix or mispronounce the -enia ending. Focus on the tri-syllabic rhythm and keep the middle -ko- and ending -ni-a distinct, with the final schwa-like sound. IPA and slow practice help solidify the pattern.
The word contains a rare combination of a long open 'oo' in leuko and an unstressed, reduced final -ia, which is not always fully pronounced in rapid speech. In careful medical speech, you hear all syllables; in quick clinical reporting, the ending may be softened to -niə. Mastery comes from chunking into three stable syllables leu-ko-pe-nia and practicing the shift between stressed and reduced vowels.
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Leukopenia derives from the Greek leuko- (white) and -penia (deficiency, lack). The combining form leuko- entered medical English through Greek roots in the 19th century as bacteriology and hematology terminology expanded. Penia comes from the Greek pénia, meaning poverty or lack, and appears in medical terms to indicate a deficit such as leukopenia (low white blood cells) or thrombocytopenia (low platelets). The word first appeared in medical literature as hematology terminology standardized in the late 1800s to early 1900s, paralleling advances in blood cell counting techniques. Over time, leukopenia has been refined to describe quantitative thresholds across age groups and clinical contexts, including oncology, infectious disease, and pharmacology, where neutropenia is a common related term when neutrophils are specifically reduced. In modern usage, leukopenia is a precise diagnostic descriptor rather than a generic “low WBC” label, and is frequently paired with absolute neutrophil count (ANC) in patient records.
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💡 These words have similar meanings to "Leukopenia" and can often be used interchangeably.
🔄 These words have opposite meanings to "Leukopenia" and show contrast in usage.
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Words that rhyme with "Leukopenia"
-nia sounds
-rd) sounds
Practice with these rhyming pairs to improve your pronunciation consistency:
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