4 syllables: La, mo, tri, gine. Stress on tri.
luh-moh-TRIJ-een
/ləmoʊˈtɹɪdʒiːn/
Lamotrigine is pronounced luh-moh-TRIJ-een (/ləmoʊˈtɹɪdʒiːn/). It has four syllables (La-mo-tri-gine), with the stress on "tri". Lamotrigine is a prescription anticonvulsant and mood stabilizer used to treat epilepsy and bipolar disorder. It functions by stabilizing neuronal membranes and modulating voltage-gated sodium channels. As a medical term, it is a multi-syllabic drug name often pronounced with careful enunciation in clinical settings.
nounLamotrigine is a prescription anticonvulsant and mood stabilizer used to treat epilepsy and bipolar disorder. It functions by stabilizing neuronal membranes and modulating voltage-gated sodium channels. As a medical term, it is a multi-syllabic drug name often pronounced with careful enunciation in clinical settings.
"The patient was prescribed lamotrigine to manage focal seizures."
"For bipolar disorder, lamotrigine can help stabilize mood without causing rapid shifts."
"The pharmacist explained the dosing schedule for lamotrigine and potential interactions."
Lamotrigine is pronounced la-MO-tri-gine, with six phonemes: /lə/ /ˈmoʊ/ /trə/ /dʒiːn/ in US; the primary stress falls on the second syllable “MO.” IPA: US /ləˈmoʊ.trəˌdʒiːn/, UK /ləˈməʊ.trɪ.dʒaɪn/, AU /ləˈmɒ.trɪ.dʒaɪn/. Start with a relaxed schwa, then a strong /oʊ/ or /əʊ/ in the second syllable, followed by /trɪ/ or /trə/ and end with /dʒaɪn/ or /dʒiːn/. Audio reference: consult a medical pronunciation resource or YouTube glossary to hear the precise cadence.
Common errors: (1) Misplacing stress, pronouncing la-MO-tri-gine with primary stress on the first syllable; (2) Slurring the -trig- cluster into a simple -tri- or -tine, losing the /dʒ/ sound; (3) Ending with a weak or silent -e, giving /ˈloʊ.mə.trɪ.dʒaɪn/ instead of /ˈmoʊ.trə.dʒiːn/. Correction: emphasize the second syllable MO and enunciate the /dʒ/ before the final /iːn/. Use slow, deliberate transitions: /ləˈmoʊ.trəˌdʒiːn/ for US, ensuring you don’t reduce the final syllable.
US tends to reduce the first syllable to a schwa /lə/ and sustain /ˈmoʊ/ with a slightly tighter /trə/ before /dʒiːn/. UK often uses /ləˈməʊ.trɪ.dʒaɪn/, with a shorter first vowel and more rounded /əʊ/ in MO, and a lighter final /aɪn/ or /iːn/ depending on speaker. Australian English may show /ləˈmɒ.trɪ.dʒaɪn/ with broader /ɒ/ and a more open final vowel. Across all accents, keep the /dʒ/ and the final /n/ clear, and avoid muting the -gine.
The difficulty lies in the multi-syllabic structure and the consonant cluster /trɪdʒ/ bridging the middle and final syllables. The /dʒ/ sound before a long /iːn/ can be tricky, and English vowel length shifts in the second syllable (MO) plus the final -gine vowel require precise tongue positioning. Practice the sequence la-MO-tri-gine with deliberate onset and coda closure to keep the phoneme boundaries clear.
Lamotrigine features a three-consonant bite before the final nasal: /ləˈmoʊ.trə.dʒiːn/. Focus on the /tr/ onset immediately after /ə/ and ensure the /dʒ/ is released clearly before the final /iːn/. A small mouth opening and a voiced /dʒ/ can help keep the final syllable crisp. IPA guidance: /ləˈmoʊ.trəˌdʒiːn/.
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Lamotrigine, a neuroactive medication, derives from a constructed pharmaceutical name rather than a traditional root in the sense of a common language word. The -trig- element echoes a pharmacological naming convention that implies tri- or triadic action, while the -gine suffix resembles other anticonvulsants such as carbamazepine or valproate in phonotactics. The prefix lam- does not signal a familiar root but was chosen to create a distinctive, pronounceable drug name that preserves a clinical-sounding phonology. First appearing in the late 20th century as researchers sought novel sodium-channel–modulating agents, lamotrigine quickly gained adoption globally, with brand-name variants like Lamictal. Its usage expanded beyond epilepsy to mood stabilization in bipolar disorder, cementing the term in medical literature and patient discussions alike.
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Words that rhyme with "Lamotrigine"
-gin sounds
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