5 syllables: I, tra, con, a, zole. Stress on con.
eye-truh-KOH-nuh-zohl
/aɪtrəˈkoʊnəˌzoʊl/
Itraconazole is pronounced eye-truh-KOH-nuh-zohl (/aɪtrəˈkoʊnəˌzoʊl/). It has five syllables (I-tra-con-a-zole), with the stress on "con". Itraconazole is a prescription antifungal medication used to treat a variety of fungal infections. It is commonly prescribed for systemic mycoses and certain skin infections, and is typically administered orally in capsule or solution form. The term refers specifically to this triazole antifungal compound, including its chemical class and brand references.
nounItraconazole is a prescription antifungal medication used to treat a variety of fungal infections. It is commonly prescribed for systemic mycoses and certain skin infections, and is typically administered orally in capsule or solution form. The term refers specifically to this triazole antifungal compound, including its chemical class and brand references.
"The patient was started on itraconazole after confirming a systemic fungal infection."
"For long courses, doctors monitor liver enzymes when prescribing itraconazole."
"Itraconazole capsules should be taken with food to improve absorption."
Pronounce as eye-TRAH-koh-nah-zol, with primary stress on the second syllable: /ˌaɪˌtrækəˈnoʊzɔl/ (US). Break it into 4 syllables: i-tra-co-na-zole. Start with a long 'i' sound, stress shifts to the 'co' element, and end with a clear 'zol' as in 'zole'. If you’re saying it quickly, keep the 'trac' portion crisp and avoid tensing the tongue at the end.
Common errors: misplacing stress (treating it as i-TRA-coNA-zol), mispronouncing the 'trac' as soft 'triss' or 'trace-uh' with a hard 'c', and slurring the final 'zole' to 'zoh'. Correction: emphasize the syllable 'na' and then 'zol', keep the 'trac' as a single cluster /træk/. Practice the sequence i-TRAC-o-naz-ol with a short, crisp 'o' in the third syllable and a distinct final /zɔl/.
In US English you’ll hear /ˌaɪˌtrækəˈnoʊzɔl/ with rhotic r and a long 'o' in 'azole'. UK English tends to reduce the second vowel slightly and use /ˌaɪˈtrækəˌnɒzɒl/ with non-rhotic r’s and a short 'o' in the final syllable. Australian tends to resemble UK but with a slightly broader vowel in 'no' and a more clipped final 'zol'. Key feature is the rhoticity and vowel quality shifting the final syllable from /ɔl/ to /ɒl/ (US vs UK/AU).
The difficulty comes from the multi-syllabic length, the three consonant clusters (trac, naz), and the final '-azole' cluster which isn’t common in everyday speech. The combination of a diphthong in the first syllable and a stressed middle syllable creates a tricky rhythm. Additionally, non-native speakers might misplace stress or merge sounds, especially the 'no' and 'zole' parts. Focus on separating the syllables and practicing the sequence i-TRAC-o-naz-ol.
Is there a silent letter in itraconazole? No. Every syllable carries a sound: i-TRA-co-NA-zole. The challenge is the triad of consonant clusters and the final -zole; ensure you articulate /træ/ in 'trac' and keep the final /zɔl/ clear rather than blending into a 'zol'.
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US: rhotic /ɹ/ in 'itraconazole' is present; vowel quality in 'no' is /noʊ/, 'ze' is /zɔl/. UK: non-rhotic, 'no' is /nɒ/; final 'zole' is /zɒl/. AU: similar to UK with slightly broader vowels; maintain non-rhoticity though some speakers show a light 'r' in connected speech. Use IPA references: /ˌaɪˌtrækəˈnoʊzɔl/ (US), /ˌaɪˈtrækəˌnɒzɒl/ (UK/AU). Accent tips: stretch the 'no' to a clear /noʊ/ in US, flatten to /nɒ/ in UK, and keep the final /zɔl/ or /zɒl/ crisp in all accents.
Itraconazole derives from the core chemical group 'triazole'—a five-membered heterocycle containing three nitrogens—combined with the prefix 'itra-' likely relating to its synthetic route and pharmacophore naming conventions in antifungal triazoles. The word first appeared in pharmaceutical literature in the 1990s as newer azole antifungals were developed to treat invasive fungal infections. The stem 'azole' is common to many antifungal drugs (fluconazole, ketoconazole, voriconazole) and signals the triazole ring, crucial for the drug’s mechanism of inhibiting ergosterol synthesis in fungal cell membranes. The initial naming often reflected structure-activity relationships and patent assignments, with generic 'itraconazole' becoming standardized across multilingual medical texts. Over time, usage broadened from clinical trials to widespread prescribing, and the name has carried into pharmacology databases and patient-facing information. The etymology thus sits at the intersection of chemical nomenclature and pharmaceutical branding, anchored by the triazole core and the tracer-prefix conventions used by medicinal chemists to identify related compounds.
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💡 These words have similar meanings to "Itraconazole" and can often be used interchangeably.
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Words that rhyme with "Itraconazole"
-zoe sounds
-ole sounds
Practice with these rhyming pairs to improve your pronunciation consistency:
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