6 syllables: En, do, can, na, bi, noids. Stress on bi.
en-doh-kan-uh-BEYE-noydz
/ɛn doʊ kæ nə ˈbaɪ nɔɪdz/
Endocannabinoids is pronounced en-doh-kan-uh-BEYE-noydz (/ɛn doʊ kæ nə ˈbaɪ nɔɪdz/). It has six syllables (En-do-can-na-bi-noids), with the stress on "bi". Endocannabinoids are naturally occurring cannabinoids produced within the body that bind to cannabinoid receptors, modulating physiological processes such as pain, mood, and appetite. They’re part of a complex signaling system that helps regulate homeostasis. The term combines endo- (inside), cannabinoid (cannabis-derived compounds), and -ids (agents), reflecting internal ligands for cannabinoid receptors. Plural form is endocannabinoids.
nounEndocannabinoids are naturally occurring cannabinoids produced within the body that bind to cannabinoid receptors, modulating physiological processes such as pain, mood, and appetite. They’re part of a complex signaling system that helps regulate homeostasis. The term combines endo- (inside), cannabinoid (cannabis-derived compounds), and -ids (agents), reflecting internal ligands for cannabinoid receptors. Plural form is endocannabinoids.
"Researchers study endocannabinoids to understand how the body maintains homeostasis in stress and energy balance."
"Endocannabinoids play a key role in pain modulation and inflammatory responses, which has implications for treating chronic conditions."
"Certain foods and exercise can influence endocannabinoid levels, affecting mood and appetite."
Pronounce as en-do-CAN-uh-buh-noydz (US) or en-duh-CAN-uh-buh-NOYDZ (UK/AU). Stress falls on can- or -noyds depending on region; treat as three syllables: en-do-can-a-buh-? Wait: actual syllable count is five: en-do-can-a-buh-nyds. IPA: US /ˌɛn.dəˌkæ.nəˈbɒnˌɔɪdz/, UK /ˌɛn.dəˌkæ.nəˈben.ɔɪdz/; AU /ˌɛn.dəˌkæ.nəˈben.ɔɪdz/. Focus on pairing can with -nɔɪdz vs -ben- in UK; listen for the -ɔɪdz ending like “boydz.” Audio reference: listen to credible sources such as Pronounce or Forvo entry for “endocannabinoids.”
Common errors include misplacing the stress on the can- or ben- syllables, and mispronouncing the -oɪdz ending as -oid or -od. Another frequent mistake is blending can-a into can-uh too quickly, producing an unclear middle. To correct: pronounce five distinct syllables en-do-cana-buh-noydz, ensuring the -noydz final cluster is clearly /nɔɪdz/ with a crisp /n/ before the /ɔɪ/ diphthong and a final voiced z. Practice slows it down at first.
In US, you’ll hear a stronger schwa in the second syllable and a slightly flatter final cluster: /ˌɛn.dəˌkæ.nəˈbɒnˌɔɪdz/. UK/ AU often retain tighter vowel quality on -ben- and a clearer /ɔɪ/ in -oydz, with final -dz preserved: /ˌɛn.dəˌkæ.nəˈben.ɔɪdz/. The rhoticity is minimal in non-rhotic British speech, so 'en' and 'd' blends may feel crisper. Practicing with region-specific audio helps internalize these shifts.
The difficulty comes from the multi-syllabic structure and the /ˌɛn.dəˌkæ.nəˈben.ɔɪdz/ rhythm, with a tense midsection and the /ɔɪ/ diphthong that many speakers split. The internal cluster can blur in rapid speech, and the final /dz/ consonant can be swallowed if you’re not careful. Focus on three strong syllables, keep the middle vowels precise, and ensure the final -oydz is voiced clearly.
Unique aspect: the sequence can be miscounted as fewer or more syllables; emphasize five syllables: en-do-can-a-buh-noydz, with stress on the -noydz or on -ben- depending on speaker. The core is the /kæ.nə/ vs /kæ.nə/ blend; keep theCan- and -noydz distinct. The word’s internal vowels glide between SCHWA and a clear /æ/ or /ə/ depending on accent. Listen to native phrases and mimic the cadence.
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US: rhotic accent; pronounces /ɹ/ clearly in the first syllables with a more rounded /ɒ/ in the -ɔɪdz ending depending on speaker. UK: non-rhotic; the final -dz remains audible; the /ə/ vowels are shorter; AU: similar to UK but with slightly flatter vowels and more lenient linking; maintain the five-syllable cadence with distinct can-a-nuh. Vowels: /ə/ vs /ɪ/ alternations and diphthong clarity for /ɔɪ/. IPA references: US /ˌɛn.dəˌkæ.nəˈbɒnˌɔɪdz/, UK /ˌɛn.dəˌkæ.nəˈben.ɔɪdz/, AU /ˌɛn.dəˌkæ.nəˈben.ɔɪdz/.
Endocannabinoids derive from endo- (from Greek endon meaning within) + cannabinoid (from the scientific naming of cannabis compounds, first used in the 1960s after the discovery of tetrahydrocannabinol [THC] and related molecules) + -ids (denoting chemical agents). The term cannabinoids originally described plant-derived compounds like THC and CBD. In the 1990s, researchers extended the idea to endogenous ligands produced by the body that interact with cannabinoid receptors (CB1 and CB2), hence endocannabinoids—ligands produced inside the body that engage the endocannabinoid system. First, the concept emerged as scientists started mapping receptor activity and signaling pathways. The modern vocabulary solidified with terms like anandamide (AEA) and 2-arachidonoylglycerol (2-AG) identified as principal endocannabinoids, establishing a comprehensive family of endogenous ligands. Over time, the understanding broadened to include receptor interactions, enzymatic degradation, and the system’s role in homeostasis, immune function, and neural plasticity. The term became standard in neuroscience and pharmacology literature by the early 2000s, evolving from a plant-origin nomenclature to a precise biomedical category of body-produced signaling molecules.
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