4 syllables: Ce, ti, ri, zine. Stress on ri.
set-ir-IZ-in
/sɛtɪˈrɪzɪn/
Cetirizine is pronounced set-ir-IZ-in (/sɛtɪˈrɪzɪn/). It has four syllables (Ce-ti-ri-zine), with the stress on "ri". Cetirizine is a second-generation antihistamine used to relieve allergy symptoms such as sneezing, itching, and runny nose. It is commonly sold as an over-the-counter oral tablet or liquid. The word is a pharmaceutical noun derived from its chemical name, with emphasis typical in medical vocabulary rather than everyday speech.
nounCetirizine is a second-generation antihistamine used to relieve allergy symptoms such as sneezing, itching, and runny nose. It is commonly sold as an over-the-counter oral tablet or liquid. The word is a pharmaceutical noun derived from its chemical name, with emphasis typical in medical vocabulary rather than everyday speech.
"She took cetirizine to ease her seasonal allergy symptoms."
"The pharmacist explained how cetirizine can be used with other allergy medications."
"Cetirizine is often preferred for its once-daily dosing."
Pronounce as sə-TEER-i-zeen with three stressed syllables: the primary stress on the second syllable TEER. IPA for US: sɪˈtɪrɪziːn, UK: sɪˈtɪrɪz.iːn, AU: sɪˈtɪrɪziːn. Start with a soft s, then a crisp TEER, followed by a short i, and finish with zeen. Think of it as ce-TI-ri-zine, with the emphasis on TI and a long -zeen at the end. For an audio cue, listen to medical pronunciation resources and repeat slowly at first, then align with natural speech tempo.
Common errors: misplacing the stress (putting it on first or third syllable instead of second), and blending or mispronouncing ‘ri’ as a long ‘ri’ sound. Another frequent mistake is elongating the final -zeen to -zeeen. Correction: place primary stress on the second syllable (ce-TI-ri-zine), use a short, clipped ‘ri’ (ɪ) and end with a clear long ‘ziːn’ (ziːn). Practice with IPA anchors: sɪˈtɪrɪziːn and mirror mouth positions as you say it aloud.
In US English, the initial s is unvoiced and the middle vowels are lax; rhoticity is present, and the final -zeen is a clear long e sound. UK English keeps a similar pattern but with slightly more clipped vowels and less rhotic influence in some speakers; AU tends to be closer to US but with notable vowel quality shifts, sometimes a slightly broader diphthong on the first syllable. Overall, the stress remains on TI, with subtle vowel shifts: US /sɪˈtɪrɪziːn/, UK /sɪˈtɪrɪzɪːn/ or /ˈsɛtɪriːzɪn/, AU /sɪˈtɪrɪziːn/. Practice with region‑specific audio to tune vowel length and rhoticity.
Key challenges are the multi‑syllabic structure and the cluster -riz- in the second half; the sequence -ti-ri- can produce a clipped or swallowed syllable if rushed. The final -zine uses a long -iːn sound that English speakers may shorten. The correct sequence is sɪˈtɪrɪziːn, with primary stress on TI and careful articulation of -ri- as ɪ and -ziːn as ziːn. Slow, deliberate repetition with IPA targets—sɪˈtɪrɪziːn—helps cement the pattern.
A distinctive feature is the mid‑ syllable “ri” having a short, lax vowel (ɪ) and the final “zine” with a long -iːn or -izin ending depending on dialect; ensure the second syllable carries the main stress and that the final -zine is not reduced. The combination of /tɪr/ versus /tɪri/ requires precise tongue position: alveolar contact for the r, and a crisp trailing z. Practice ensures a steady i in the penultimate syllable and a clear long ē Sound at the end.
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Cetirizine derives from the chemical root cetyl (a hydrocarbon chain) combined with the amino-pyridine suffix and the hydrophilic group that characterizes many second‑generation antihistamines. The term first entered medical and pharmaceutical usage in the late 20th century as generic nomenclature for a specific piperazine‑pyridazine antihistamine compound. Linguistically, the root ces- or cet- reflects its chemical origin in cetyl groups, while -irizine is a conventional suffix used in several antihistamines (loratadine, fexofenadine share the -dine/-ine family). The first marketed drug with this exact name appeared in the 1990s, with the active ingredient widely recognized as a non‑sedating antihistamine. Over time, cetirizine became a household term worldwide, verging into generic usage for the class of second‑generation antihistamines, while remaining a precise chemical identifier in pharmacology. The evolution of its meaning mirrors a shift from a chemical descriptor to a widely used therapeutic name, marking its entry into common medical parlance and consumer health vocabulary.
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Words that rhyme with "Cetirizine"
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