5 syllables: An, a, phy, lax, is. Stress on lax.
an-uh-fuh-LAK-sis
/ˌænəfəˈlæksɪs/
Anaphylaxis is pronounced an-uh-fuh-LAK-sis (/ˌænəfəˈlæksɪs/). It has five syllables (An-a-phy-lax-is), with the stress on "lax". Anaphylaxis is a severe, potentially life-threatening allergic reaction that occurs rapidly after exposure to an allergen. It involves multiple body systems, including the skin, respiratory, and cardiovascular systems, and requires immediate medical treatment. It is typically characterized by symptoms such as swelling, hives, shortness of breath, and dizziness.
nounAnaphylaxis is a severe, potentially life-threatening allergic reaction that occurs rapidly after exposure to an allergen. It involves multiple body systems, including the skin, respiratory, and cardiovascular systems, and requires immediate medical treatment. It is typically characterized by symptoms such as swelling, hives, shortness of breath, and dizziness.
"The patient developed anaphylaxis after being stung by a bee."
"Medical staff administered epinephrine promptly to treat the anaphylaxis."
"She carries an epinephrine auto-injector in case of anaphylaxis."
You say an-uh-fuh-LAK-sis, with primary stress on the LAK syllable and a light, quick -sis ending. IPA: US/UK/AU /ˌænəfəˈlæk.sɪs/. Start with /æ/ as in cat, then /nə/ (schwa-like) before /fə/ or /fə/ blend, then /ˈlæk/ with a crisp /l/ and /k/, and end with /sɪs/. Think: 'AN-uh-fuh-LAK-sis'.
Common mistakes: misplacing the primary stress too early (say AN-uh-fuh-LAK-sis? actually stress should be on LAK). Another is softening the /læk/ into a vague /læksɪs/ or saying /-lax-/-laxe/. Correction: clearly produce /ˌænəfəˈlæk.sɪs/, with crisp /l/ and a short, unstressed /ɪs/ at the end. Ensure the /æ/ in the first syllable is short, and avoid turning /læk/ into /lækz/.
In US/UK/AU, the main differences are vowel quality and rhoticity. US tends to be rhotic with r-colored vowels; the /æ/ in the first syllable remains central, with /ə/ as a schwa. UK often has a tenser vowel in /æ/ and slightly less rhotic influence in some regions, but /ˌænəfəˈlæk.sɪs/ remains consistent. Australian generally aligns with non-rhotic tendencies, but with vowel merging that can slightly soften the final -sis; the core syllable stress on LAK remains. IPA remains /ˌænəfəˈlæk.sɪs/ across mainstream accents.
It’s a multisyllabic, stress-timed word with three weak syllables surrounding a strong central /læk/ cluster. The combination of schwa-like /ə/ in the second syllable and a crisp /ˈlæk/ can trip speakers. The syllable count (5) plus the final /sɪs/ requires careful pacing to avoid truncating the ending. Focus on the stressed syllable and articulate the consonant cluster /læk/ clearly to avoid mispronouncing as 'anaphylastis' or 'anaphylaxsis'.
A notable nuance is the quick, light pronunciation of the two unstressed syllables before the main stress: /ˌænə/ can glide to a soft /ə/ or /ɪ/ before /fə/; but ensure the /ˈlæk/ is strong and that /sɪs/ at the end is concise, not elongated. Some speakers may add an extra syllable or misplace stress: keep the primary emphasis on the /læk/ to prevent confusion with similar-sounding medical terms.
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US: rhotic accent—tend to maintain /r/ only when present in adjacent syllables; the /æ/ in first syllable can be a bit lax in rapid speech; keep /ə/ unstressed in the second syllable. UK: more clipped vowels; maintain clear /æ/ and avoid overly rounded /ə/ in the second syllable. AU: tends toward non-rhotic tendencies with light /ɪ/ in the final syllable; keep the final /sɪs/ crisp without voicing. IPA reminders: US /ˌænəfəˈlæk.sɪs/, UK /ˌænəfəˈlæk.sɪs/, AU /ˌænəfəˈlæk.sɪs/.
Anaphylaxis comes from the Greek roots an-, meaning against or up, and -aphylaktikos, meaning preventing or guarding, combined with -asis from Greek -asis for a state or condition. The term was formed in the late 19th to early 20th century as medical science sought a precise term for a rapid, life-threatening allergic reaction. The prefix ana- (again, up, back) is common in medical terminology, while phylaxis derives from phylassein (to guard, to protect). Early usage appeared in clinical literature describing dangerous systemic allergic responses, and over time it has standardized to denote a brisk, multi-system reaction that can progress to shock if untreated. The word encapsulates a dangerous protective failure of the body’s tolerance to otherwise harmless substances, emphasizing urgency in recognition and treatment. It is now a cornerstone term in emergency medicine, allergy practice, and patient education about epinephrine use and avoidance strategies.
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Words that rhyme with "Anaphylaxis"
-xis sounds
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