7 syllables: A, gra, nu, lo, cy, to, sis. Stress on lo.
ag-ran-nyoo-LOH-sis
/ˌæɡˌræn.njuːˈloʊ.sɪs/
Agranulocytosis is pronounced ag-ran-nyoo-LOH-sis (/ˌæɡˌræn.njuːˈloʊ.sɪs/). It has seven syllables (A-gra-nu-lo-cy-to-sis), with the stress on "lo". Agranulocytosis is a rare, potentially life-threatening hematologic condition marked by an extremely low level of granulocytes, especially neutrophils. It can result from adverse drug reactions or bone marrow failure. Early recognition and treatment are critical to reduce infection risk and complications.
nounAgranulocytosis is a rare, potentially life-threatening hematologic condition marked by an extremely low level of granulocytes, especially neutrophils. It can result from adverse drug reactions or bone marrow failure. Early recognition and treatment are critical to reduce infection risk and complications.
- You often misplace primary stress on a later syllable, say agra-NU-lo-sis instead of ag-ra-NU-lo-cy-to-sis. Fix: rehearse by clapping each syllable and placing stress on the 4th, then 5th. - The /njuː/ vs /njuː/ can be tricky; in US, /ɪ/ or /ɪə/ may color the 'nu' sound. Correction: keep /njuː/ as a unit, with the /j/ glide clearly integrated. - The ending -sis can be shortened in casual speech; maintain crisp /sɪs/ to preserve the term’s medical clarity. Practice slow, then accelerate while keeping the same rhythm.
"The patient developed agranulocytosis after starting a new antithyroid medication."
"Her blood test revealed agranulocytosis, necessitating immediate isolation procedures and antibiotic coverage."
"Clinicians monitor for agranulocytosis in patients taking certain immunosuppressants."
Pronounce as ˌa-ɡra-nu-lo-cy-to-sis with primary stress on the fourth syllable: ag-ra-NU-lo-cy-to-sis. IPA US/UK: ˌæɡ.rɪ.njuːˈlɒ.sɪ.sɪs. Mouth positions: start with a light schwa-like initial, then /ɡr/ cluster, /ɪ/ or /ɪ/ near 'nu', /ˈlɒ/ or /ˈlɔ/ depending on accent, and end with /sɪs/. Audio reference available in standard medical pronunciation resources.
Common errors: stressing the wrong syllable (placing stress on a later syllable), mispronouncing the 'gran' as /ɡræn/ instead of /ˌɡreɪ/ in some accents, and misarticulating the /juː/ sequence after /n/. Correction: pronounce as ag-ra-NU-lo-cy-to-sis with accurate split of syllables; use /juː/ only after /njuː/ in British English when appropriate, and keep the 'cy' as /si/ rather than /saɪ/ in many dialects.
US tends to /ˌæɡ.rɪ.njuːˈlɒ.sɪ.sɪs/ with non-rhotic ending, UK often /ˌæɡ.rɪ.njuːˈlɒ.sɪ.sɪs/ with similar rhoticity in careful speech, AU can show slight vowel length differences and a marginally flatter /ɒ/ to /ɔ/ depending on region. The main differences lie in rhoticity and vowel quality of /ɔ/ vs /ɒ/, and the treatment of the /ɪ/ before /sɪs/.
Key challenges include the long multisyllabic structure, the sequence -nu-lo-cy-, and the final -sis ending that can be reduced in rapid speech. The consonant cluster /ɡr/ and the /juː/ sequence after /n/ require precise tongue retraction and lip rounding. Additionally, the full four-syllable rhythm must be maintained to avoid blur. Focusing on deliberate syllabic chunking and steady tempo helps reduce mispronunciations.
A distinctive feature is the unstressed initial cluster and the strong secondary stress pattern introducing the /ˌæɡ.rɪ/ sequence, followed by clear enunciation of -lu-cy-to-sis. The /juː/ in /njuː/ behaves near a liaison-like sound in some dialects. Paying attention to the /ɡr/ blend and keeping -lɒ/ or -lɔ/ precise in practice distinguishes precise medical pronunciation.
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US: rhotic accent, /æɡ.rɪ.njuːˈlɒ.sɪ.sɪs/; UK: non-rhotic or mildly rhotic, /æɡ.rɪ.njuːˈlɒ.sɪ.sɪs/ with stronger; AU: tends toward /ɒ/ > /ɔ/ in some regions and /juː/ may compress to /ju/; Keep /æ/ in first syllable steady, ensure /ɡr/ cluster light yet firm, and preserve /njuː/ sequence. Use IPA guides and Forvo samples for reference.
Agranulocytosis derives from Greek a- (without), granulocyte (granular white blood cell with cytoplasmic granules) from granulum ‘a small grain’ + cytosis (a circulating cell condition, from Greek kytos ‘hollow vessel’). The medical term aggregates a- (without) + granulocyte + -osis (a medical condition). First used in the early 20th century as hematology advanced, and pharmacovigilance linked granulocyte suppression to drug reactions, especially in the 1940s–1960s with the rise of cytotoxic therapies. The word reflects a precise laboratory finding rather than a general infection risk, distinguishing it from broader leukopenia. Over time, agranulocytosis has remained a critical diagnostic keyword in drug safety and hematology, signaling the need for urgent evaluation when neutrophil counts fall below critical thresholds. The term emphasizes a specific deficit (granulocytes) rather than a general white cell decrease, shaping targeted clinical management and research into predictive risk factors and protective strategies.
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Words that rhyme with "Agranulocytosis"
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