Pathology

Glioblastoma is a highly aggressive brain tumor classified as a grade IV astrocytoma. It typically presents rapid growth and diffuse infiltration into surrounding brain tissue, making treatment challenging. The term combines Greek roots for 'glio' (glial cells), 'blast' (bud/immature cell), and 'oma' (tumor).

Glomerulus is a tiny, tufted network of capillaries in the nephron of the kidney where blood filtration begins. It is surrounded by Bowman's capsule and is essential for ultrafiltration, forming filtrate that becomes urine. The term also appears in other biological contexts to describe similar knot-like network structures.

Granulocyte is a type of white blood cell containing granules that stain with basic dyes. It includes neutrophils, eosinophils, and basophils, each playing roles in immune defense. Granulocytes are typically produced in bone marrow and participate in innate immune responses and inflammation. They are distinguished by their cytoplasmic granules and multilobed nuclei under a light microscope.

Granulocytopenia is a hematologic condition characterized by an abnormally low number of granulocytes, especially neutrophils, in the blood. It can increase infection risk and may result from drugs, immune disorders, or bone marrow issues. The term emphasizes a deficiency of granulocytes, a crucial white blood cell type, impacting immune defense.

Granulocytosis is a medical term describing an elevated level of granulocytes in the blood. It is used mainly in clinical contexts and research to indicate an abnormal increase in certain white blood cells, impacting immune response. The term reflects hematology terminology and is encountered by specialists and informed patients. Typically, its usage appears in diagnostic reports and scholarly articles.

Granuloma is a small area of inflammation, typically a cluster of immune cells, which forms in response to infection, injury, or irritants. It can occur in various tissues, often indicating a chronic or persistent immune reaction. The term is used across medical and scientific contexts to describe this nodular inflammatory process.

Granulomatous is an adjective describing tissue or lesions that contain granulomas—small nodular inflammatory clusters formed to wall off foreign substances. It is used mainly in medical contexts to characterize chronic inflammatory processes, such as granulomatous diseases. The term conveys a microbiological and histopathological nuance beyond generic inflammation.

A hematoma is a localized swelling filled with blood outside of a blood vessel, usually caused by injury. It forms when blood leaks from damaged capillaries and collects in surrounding tissues, producing a raised, sometimes discolored lump. The term is used in medical reporting and patient contexts to describe this collection of clotted blood beneath the skin or within organs.

Hemorrhage (noun) refers to a discharge of blood from a ruptured blood vessel, either externally or internally. It can denote significant bleeding due to injury, illness, or surgical procedures, and is used in medical and everyday contexts. The term also appears metaphorically to describe rapid, excessive loss of something valuable.

Hepatitis is an inflammatory disease of the liver, caused by viral infection, alcohol use, or autoimmune factors. It commonly presents with jaundice, fatigue, and abdominal pain, and can be acute or chronic. The term covers several distinct conditions (types A–E) that affect liver function and health outcomes.

Hepatocellular is a medical term describing anything related to liver cells, typically used in pathology and hepatology. It combines hepat- (liver) with -ocellular (cellular), referring to liver parenchymal cells. The word is primarily used in formal scientific writing and clinical contexts to specify cellular origin within hepatic tissue.

A hepatocyte is a principal liver cell specializing in metabolic, detoxification, and protein-synthesis tasks. It is polygonal, polyhedral, and organized into plates within hepatic lobules, performing essential biochemical processes that sustain liver function. The term combines Greek roots for liver (hepar) and cell (kytos), reflecting its cellular liver role and specialized activities.

Hepatoma is a malignant liver tumor, typically hepatocellular carcinoma that may also refer to rare liver tumors. The term combines Greek roots for liver (hepar) and tumor (oma), and is used in medical contexts to describe a primary liver cancer or hepatic neoplasm. It is a specialized, technical word encountered mainly in clinical literature and pathology.

Hepatosplenomegaly is a medical condition in which the liver (hepato) and the spleen (spleno) are enlarged. It indicates systemic disease or organ involvement and is typically diagnosed via physical exam and imaging. The term is used mainly in clinical contexts and scholarly writing to describe concurrent hepatomegaly and splenomegaly.

A histiocyte is a type of immune cell derived from monocytes that resides in tissues, where it engulfs pathogens and debris. It plays roles in antigen presentation and inflammatory responses. The term is used mainly in pathology and immunology contexts to describe tissue-resident macrophage-like cells.

Histology is the branch of biology that studies the microscopic structure of tissues. It involves preparing thin tissue sections, staining them, and examining them under a microscope to understand tissue organization, cellular relationships, and function. The word combines Greek roots related to tissue and science, and it’s a foundational tool in pathology, anatomy, and biomedical research.

Hyalinization is the process of forming or becoming hyaline—an extracellular, glassy, translucent material—or the transformation of tissue into a hyaline-like substance. In biology and medicine, it often describes the conversion of structures toward a clear, pale, glassy appearance, typically involving protein accumulation and altered tissue architecture. The term is used across histology, pathology, and developmental biology to denote a specific, glassy degenerative or formative change.

Hypercellularity refers to an unusually high density of cells within a tissue or organ, often indicating a pathologic or neoplastic process. It can also describe tissues with increased cellularity due to reactive or developmental factors. In medical contexts, it is used to contrast with hypocellularity, where few cells are present. The term combines hyper- (excess) with cellularity (cell density).

Hyperchromasia is a morphological feature seen in cells with excessive DNA content, giving them an intensely staining, dark appearance under light microscopy. It denotes markedly increased chromatin density, often associated with cellular atypia and malignancy. The term is used in pathology to describe this nuclear characteristic in contrast to normal chromatin distribution.