4 syllables: pe, rox, i, dase. Stress on rox.
puh-ROHK-seye-dayz
/pəˈroʊksaɪdeɪz/
peroxidase is pronounced puh-ROHK-seye-dayz (/pəˈroʊksaɪdeɪz/). It has four syllables (pe-rox-i-dase), with the stress on "rox". Peroxidase is a group of enzymes that catalyze the reduction of hydrogen peroxide, converting it into water and an oxidized substrate. These enzymes play key roles in protecting cells from oxidative damage and in various biosynthetic pathways. The term combines 'peroxide' and the enzyme suffix '-ase,' reflecting its catalytic function. In biochemistry, peroxidases are studied for their kinetics, substrates, and applications in diagnostics and research.
Peroxidase is a group of enzymes that catalyze the reduction of hydrogen peroxide, converting it into water and an oxidized substrate. These enzymes play key roles in protecting cells from oxidative damage and in various biosynthetic pathways. The term combines 'peroxide' and the enzyme suffix '-ase,' reflecting its catalytic function. In biochemistry, peroxidases are studied for their kinetics, substrates, and applications in diagnostics and research.
- You might misplace the main stress on the first or second syllable. The correct high-energy stressed syllable is typically in the third part: peroxi-DASE or pe-ROX-i-dase depending on dialect; aim for a crisp /deɪz/ ending. - Another error is pronouncing the final -dase as /-dəs/ (schwa). Always end with /-deɪz/ to keep the word’s meaning clear. - The beginning consonant cluster /pərɒk/ or /pəɹɒk/ can become too rounded or overly aspirated; practice a clean, unaspirated initial /p/ followed by a light /ə/ and crisp /ɹ/.
"The horseradish peroxidase (HRP) assay is a standard in molecular biology for detecting small amounts of analyte."
"Some plants express peroxidases as part of their defense against pathogens."
"Researchers measured peroxidase activity to assess oxidative stress in the tissue samples."
Pronounce as /pə-ROK-si-ˌdeɪz/ (US) or /ˌpɜːˈrɪdɒkˌeɪz/ (UK). The primary stress lands on the third syllable, with a secondary emphasis on the first syllable in many cases. Break it into four sounds: /pə/ (short, relaxed first consonant-vowel), /ˈrɒk/ or /ˈrɪd/ depending on dialect, then /si/ as a light syllable, and /ˌdeɪz/ for the final rhyming -dase. Focus on the /dʒ/ or /z/ onset in the last syllable, not a hard /t/ or /d/ alone. Listening to HRP pronunciations will help you match the cadence.
Common errors include misplacing the stress (putting it on the wrong syllable), pronouncing -dase as /-dəs/ (schwa) instead of /-deɪz/, and mispronouncing the /ɹ/ or /p/ cluster at the start. Correction: stress the third syllable: pə-ROX-i-dase with /ˈ/ around the /dɪ/ region, pronounce the ending as /deɪz/, and keep the initial /p/ and /ɹ/ crisp without over-articulation. Practice with slow, then accelerated repetition to lock the rhythm.
In US, you’ll hear /pə-ɹɒkˌsaɪˈdeɪz/ with rhotacized /ɹ/ and strong /ɒ/ or /ɑ/. UK tends to /ˌpɜːrɪˈdɒkˌeɪz/ with less rhoticity in some regions and a clearer separation of syllables. Australian often combines a flatter vowel quality with a more relaxed /ɹ/ and a longer final /eɪz/. Regardless, the final /deɪz/ is stable; focus on the stressed syllable and the /d/+'eɪz' ending.
It’s a multi-syllabic, multisyllabic word with three prominent consonant clusters (p-kr-ks, -dase). The tricky parts are the /ɹ/ within a tensed, syllabic middle section and the final /deɪz/ that should not sound like /dəs/. You’ll also want to maintain even stress across the earlier syllables without thinning the middle /ɒk/ into a quick blur. Use slow drills, then speed up while keeping the final -dase clear.
No silent letters in standard pronunciation. Each syllable carries sound: /pə-ɹɒkˌsaɪˈdeɪz/. However, in some fast speech variants, the /si/ can be reduced slightly, but the /deɪz/ remains audible. Being precise with the /s/ and /d/ in the penultimate and final syllables helps maintain clarity.
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- US: rhotic /ɹ/ is strong; the second syllable often has a schwa preceding a strong /ɡ/-like onset in some fast speech, but keep it as /ɹɒk/ with a short schwa. - UK: less rhoticity; /ˈpɜː(r)ɪˈdɒkˌeɪz/ widely used; ensure /ɒ/ in the stressed syllable is open and rounded. - AU: flatter vowels, lighter rhotics; /ˈpɜrɪˈdɒkˌeɪz/ with a more even vowel landscape; maintain final /eɪz/ with clear /z/ voice. Reference: IPA for precise targets; emphasize final /eɪz/.
The word peroxidase derives from per- (through, by) + oxidize (to combine with oxygen or remove hydrogen) and the enzyme suffix -ase, indicating a catalytic protein. The concept emerged from early 20th-century enzymology, where scientists sought enzymes that could decompose hydrogen peroxide, a potentially harmful byproduct of cellular respiration. The term aligns with other enzymes ending in -ase that act on substrates such as oxidases and reductases. First in use in the mid-20th century, peroxidases were characterized across species, from horseradish to plants and microorganisms, highlighting the conserved catalysis of hydrogen peroxide. The etymology tracks from Latin per- (through) and Greek oxidize (to give oxygen), with -ase a modern bio-chemical suffix. Over time, peroxidase designations expanded to specific enzymes like horseradish peroxidase (HRP) and lignin peroxidase, each defined by their substrate specificity and kinetic properties. Historical literature shows evolving understanding of their mechanisms, active-site histidine residues, and heme cofactors underlying catalytic activity, reinforcing the term’s identity as a class of oxidative enzymes rather than a single molecule alone.
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Words that rhyme with "peroxidase"
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