4 syllables: Pe, ri, stal, sis. Stress on stal.
pur-is-TAL-sis
/pɚɪˈstælsɪs/
Peristalsis is pronounced pur-is-TAL-sis (/pɚɪˈstælsɪs/). It has four syllables (Pe-ri-stal-sis), with the stress on "stal". Peristalsis is the wave-like muscular contractions that move contents through tubular organs, notably the digestive tract. It involves coordinated, sequential squeezing and relaxation of smooth muscle to propel material forward. The term is used in physiology and medicine to describe this essential, rhythmic motility pattern.
nounPeristalsis is the wave-like muscular contractions that move contents through tubular organs, notably the digestive tract. It involves coordinated, sequential squeezing and relaxation of smooth muscle to propel material forward. The term is used in physiology and medicine to describe this essential, rhythmic motility pattern.
How to Pronounce Peristalsis
"Doctors described the esophagus’ peristalsis as a coordinated wave that pushes food downward."
"Impaired peristalsis can delay gastric emptying and cause symptoms like bloating."
"During the exam, the clinician discussed peristalsis as the mechanism behind intestinal movement."
You pronounce it as Pĭ-Rĭ-STĂL-SĬS with the primary stress on the second syllable: /ˌpɛrɪˈstælɪs/ in US transcription. Break it into four syllables: pe-rist-al-sis. Start with a short “pe” (like pet), then a quick “ri” reducing vowel length, stress on “stál,” and end with a light “sis.” If you’re unsure, imagine saying ‘per-i-STAL-sis’ with emphasis on STAL.
Common errors: 1) Stressing the first syllable (PÉ-ris-tal-sis) instead of the second. 2) Slurring the middle consonant cluster into /stl/ or mispronouncing /stæl/ as /stɑl/. 3) Misplacing the final -sis as /sɪs/ vs /səs/. Correction tips: say per- as /pə/ or /ˈpɛr/ depending on speaker, ensure the second syllable has primary stress /ˈstæl/ with a clear /t/ and short /æ/; finish with a light /sɪs/ or /səs/ depending on speed. Practice slow, then speed up while maintaining the pulse.
US: /ˌpɛrɪˈstælɪs/ with clearer rhotics; UK: /ˌpɪərɪˈstælɪs/ or /ˌpɪˈrɪstəlsɪs/, less rhoticity in unstressed syllables; AU: /ˌpɪˈriːstələsɪs/ or /ˌpɜːrɪˈstælɪs/ depending on speaker, vowels may be more centralized and non-rhotic. The key differences lie in vowel quality and rhotic vs non-rhotic pronunciations, vowel length, and the strength of the /ɜː/ vs /eɪ/ or /ə/ in certain syllables.
The difficulty comes from the multi-syllabic structure and the stress pattern on the third syllable in typical US usage, along with the /st/ cluster in the middle and the final -sis where /sɪs/ may reduce to /səs/ in rapid speech. Distinctive affrication of /t/ in the /st/ cluster and the subtle vowel shifts between /ɪ/ and /æ/ can challenge non-specialists. Practicing with minimal pairs and slow tempo helps stabilize the sequence.
A distinctive feature is the secondary stress tendency on the -sis ending in rapid or clinical speech, frequently reduced to /sɪs/ or /səs/ while maintaining the /stæ/ vowel in the penultimate syllable. This word also features a strong alveolar /t/ tap-like quality within the middle cluster and a contrast between /æ/ and /ɪ/ vowels in the second and third syllables that affects intelligibility in some accents.
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US/UK/AU differences: US tends toward /ˌpɛrɪˈstælɪs/ with a stronger /r/ and rhoticity; UK leans to /ˌpɪərɪˈstælɪs/ and less rhoticity in informal speech; AU often merges vowels slightly, producing /ˌpɪˈrɪstəlsɪs/ or /ˌpeːrəˈstæləsɪs/ depending on region. Vowel differences: /ɛ/ vs /ɪ/ in the first stressed syllable, /æ/ vs /ɪ/ in the third; rhotics in US maintain /r/ whereas UK/AU may drop postvocalic r in non-rhotic contexts. IPA references: US /ˌpɛrɪˈstælɪs/, UK /ˌpɪəˈstæləsɪs/, AU /ˌpɪəˈstæləsɪs/.
Peristalsis comes from the Greek peri- meaning around, + histemi meaning to stand or place, and -sis indicating a process. The term was adopted into medical vocabulary in the 19th century as scientists described rhythmic muscular contractions that propel contents through hollow organs. Its earliest formulations appear in early physiologic texts when researchers contrasted peristaltic movement with segmental segmentation and other motor patterns. The root peri- conveys the circular or surrounding action, histemi contributes the sense of standing or placing, and -sis marks a process or condition. Over time, the concept expanded beyond the esophagus to include intestinal, reproductive, and vascular motility phenomena, though the canonical sense remains a coordinated, directional wave of smooth muscle contraction. The word’s usage increased with advances in gastroenterology and motility studies, and it is now a standard term in anatomy, physiology, and clinical medicine, frequently appearing in both descriptive and pathophysiological contexts. The evolution reflects a growing understanding of how orderly muscular sequences generate propulsion, prevent backflow, and coordinate with sphincters across organ systems.
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Words that rhyme with "Peristalsis"
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