4 syllables: ni, tro, gen, ase. Stress on ni.
NEYE-troh-juh-nayz
/ˈnaɪtɹoʊdʒənˌeɪz/
nitrogenase is pronounced NEYE-troh-juh-nayz (/ˈnaɪtɹoʊdʒənˌeɪz/). It has four syllables (ni-tro-gen-ase), with the stress on "ni". Nitrogenase is an enzyme complex essential for the biological fixation of atmospheric nitrogen into ammonia, a form usable by living organisms. It catalyzes the reduction of N2, a reaction that requires substantial energy input, typically from ATP, and operates within certain microbial systems. The term denotes both the enzyme and its activity, foundational to the global nitrogen cycle.
Nitrogenase is an enzyme complex essential for the biological fixation of atmospheric nitrogen into ammonia, a form usable by living organisms. It catalyzes the reduction of N2, a reaction that requires substantial energy input, typically from ATP, and operates within certain microbial systems. The term denotes both the enzyme and its activity, foundational to the global nitrogen cycle.
"Researchers studied nitrogenase activity in Azotobacter to understand nitrogen fixation under varying oxygen conditions."
"Mutations in the nitrogenase gene can drastically reduce a microbe's ammonia production."
"The nitrogenase complex is highly sensitive to oxygen, which can inhibit its catalytic function."
Break it as ni-TO- ge- n- ase. IPA: /ˌnaɪ.trəˈdʒiː.nəs/. Syllable by syllable: ning (ny) with /ˈnaɪ/ then /trə/ as schwa+r, then /ˈdʒiː/ with a long E, and final /nəs/ with a soft, unstressed -əs. Primary stress on the third syllable block: di-JEE- nehs; keep the /dʒ/ as in judge and avoid turning it into a /ʒ/ chunky sound. Mouth: start with a light front-high tongue for /nɪ/ then lift to /trə/; glide into /dʒiː/ by raising the front of the tongue into a /dʒ/ release, then finish with a relaxed /nəs/. Audio reference: think of “ny- tro- JEE- nas,” with a crisp /dʒ/.
Common errors: 1) misplacing stress, treating it as ni-TROH-gen-ASE; 2) turning /dʒiː/ into a hard /i/ or /ji/ cluster; 3) over-syllabicating the middle /tə/ portion or deleting the schwa. Correction: keep /ˌnaɪ.trəˈdʒiː.nəs/, stress on the /ˈdʒiː/ syllable, ensure the /dʒ/ is a single affricate, and reduce the middle vowel to a quick /trə/ not /trɒ/. Practice with slow pace then speed up to natural cadence, tapping the syllable boundaries.
US/UK/AU share the same IPA skeleton /ˌnaɪ.trəˈdʒiː.nəs/ but vowel quality shifts: US vowels are often tenser in /ə/ and /iː/; UK tends to slightly more clipped /ə/ and a crisp /dʒiː/; AU often aligns with UK on vowels but may be broader in the /ə/ and slower in the final syllable. Rhoticity affects the 'trə' portion subtly; all three keep the /dʒiː/ as a prominent long E. Practice listening to region-specific scientific talks for perceptual equivalence.
Two main challenges: the multi-syllabic length and the /dʒiː/ sequence in the middle can trip speakers who default to simpler, flatter pronunciations. The /ˌnaɪ/ onset with the /trə/ transition requires precise tongue positioning, and the final /nəs/ can be swallowed in rapid speech, changing the word’s shape. Focus on maintaining stress pattern and clearly articulating the long /iː/ before the final /nəs/ to maintain intelligibility, especially in technical discussions.
Notably, the strong /dʒ/ onset in the third syllable stands out, created by the /dʒ/ affricate before a long /iː/. The sequence ni-trə- highlights a slight reduction to /trə/ rather than full vowel clarity in rapid speech. Also, the second syllable is lightly stressed as /trə/ instead of carrying heavy emphasis. Practitioners should emphasize the pentagonal rhythm: ny-TRUH-jee-nuhs, with the long E sound clearly maintained.
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Nitrogenase derives from nitrogen, the chemical element, plus the Greek suffix -ase, used in biology to denote enzymes. The word nitrogen originates from Latin nitro- and Greek genos, gradually acquiring meaning related to the element and its atmospheric form. The suffix -ase appeared in the 19th century as part of enzyme nomenclature and was applied broadly to catalysts in biology. The specific term nitrogenase was coined to identify the enzyme complex responsible for reducing molecular nitrogen (N2) to ammonia (NH3). First formal usage traces to early 20th-century biochemistry as scientists differentiated the nitrogenase complex from other nitrogen-metabolizing enzymes. Over time, nitrogenase has become a focal term in microbiology, biochemistry, and agricultural science, particularly in discussions of nitrogen fixation, ATP-dependent catalysis, and anaerobic to microaerophilic conditions that influence activity. The historical development reflects advances in molecular biology, gene sequencing, and structural elucidation of the Mo-Fe and Fe-Fe nitrogenase components in various diazotrophic organisms.
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💡 These words have similar meanings to "nitrogenase" and can often be used interchangeably.
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Words that rhyme with "nitrogenase"
-ase sounds
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# Nitrogenase Pronunciation Master Guide
