4 syllables: myo, fib, ri, llar. Stress on fib.
meye-oh-FIB-ril-ur
/ˌmaɪ.oʊˈfɪbɹɪlɚ/
myofibrillar is pronounced meye-oh-FIB-ril-ur (/ˌmaɪ.oʊˈfɪbɹɪlɚ/). It has four syllables (myo-fib-ri-llar), with the stress on "fib". Myofibrillar describes anything relating to the myofibrils, the contractile fibers within muscle cells. It is used in biology and medicine to discuss structure, organization, or pathology of muscle tissue at the microscopic level. The term combines “myo-” (muscle) with “fibrillar” (thread-like fibers).
Myofibrillar describes anything relating to the myofibrils, the contractile fibers within muscle cells. It is used in biology and medicine to discuss structure, organization, or pathology of muscle tissue at the microscopic level. The term combines “myo-” (muscle) with “fibrillar” (thread-like fibers).
- Pronouncing the stress on the first syllable as MY-oh-fibril-ar instead of mi-O-fí-bril-ar; this flattens the rhythm. - Slurred /oʊ/ into /o/ or /əʊ/ leading to a shorter onset; keep the /oʊ/ long and distinct. - Mispronouncing /fɪ/ as /fiː/ or using a hard /ɡ/ for the 'gr' portion; ensure /fɪ/ is short, pure. - Dropping or softening the final 'ar' as /ə/; in US, aim for /ɚ/ or /ə/ with clear r-coloring, in UK typically /ə/ without strong rhotic r. - Velarizing the /l/ at the end; keep a light, alveolar /l/ followed by a relaxed tongue. Correction tips: slow down to segment syllables, practice with minimal pairs, and use a mirror to monitor lip rounding around /oʊ/ and /br/ clusters.
"The biopsy showed myofibrillar hypertrophy consistent with the athlete's training."
"Researchers investigated myofibrillar disarray in the diseased muscle."
"The sample had intact myofibrillar alignment under high-resolution imaging."
Break it as /ˌmaɪ.oʊˈfɪ.brɪ.lɚ/. Primary stress on the second-to-last syllable: fio-BRIL-ar with secondary emphasis on the first syllable. Start with /maɪ/ (like I or my), glide to /oʊ/ (long o), then /ˈfɪ/ (short i), followed by /brɪ/ (brh-ih), and end with /lɚ/ (l-ER). In careful speech, pronounce as three major chunks: my-o-fibril-ar, with the core emphasis on the 'fibril' portion.
Common errors include stressing the wrong syllable (placing emphasis on 'my' or 'o'), and mispronouncing the /fɪ/ as /fiː/ or conflating /brɪ/ with /brə/. Another pitfall is a reduced final syllable, pronouncing it as /-lɚ/ or dropping the /l/ altogether. Correction: keep the main stress on the 'fibril' segment, ensure /maɪoʊ/ is precise, and articulate the final /lɚ/ with a clear rhotic vowel in US usage.
United States typically rhymes the final -ar as /-ɚ/ with a rhotic 'r'. UK often reduces the final syllable slightly, delivering /-lə/ or /-lə/ and less rhotic emphasis in rapid speech. Australian pronunciation aligns closely with US in the core vowels but can show a lighter /ɹ/ in the final syllable and a flatter pitch. Across accents, the middle 'fibril' maintains /ˈfɪ.brɪl/ but vowel color can shift: US /fɪ/, UK /ˈfaɪ.brɪl/ would be less common; more typical is /ˈfɪ.brɪl/ with a crisp /ɪ/.
It combines a multi-syllabic, stress-on-midword pattern with a cluster '/br/' followed by a light /ɪ/ vowel and a rhotacized final syllable in US English. Beginners stumble over the /maɪoʊ/ onset and the 'fibril' sequence, plus the 'l' and 'r' closely adjacent in some accents. Focusing on three tips—keep the primary stress on the 'fibril' part, maintain a clear /ɪ/ in the middle, and finish with a resonant /lɚ/ or /lə/ depending on accent—helps overcome the challenge.
A distinctive feature is the junction between /oʊ/ and /fɪ/ where the glide may be slightly compressed in fast speech, giving a quick transition from long O to a short short i. Another nuance: the final -ar in American speech often retains a crisp rhotic vowel, while in British English it may be less rhotic and drop the schwa in fast delivery. Paying attention to the diphthong glide and final rhoticization makes these subtleties audible.
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- US: emphasize rhotic final /-ɚ/, ensure stressed /ˌmaɪ.oʊˈfɪ.brɪ.lɚ/ with crisp /br/ cluster. - UK: reduce rhoticity, final may be /-lə/ or /-lə/; maintain clear /ˈfɪ/ and light /l/; avoid overly aggressive r coloring. - AU: blend US and UK traits; sometimes softer rhotics, slightly flatter vowels; preserve /oʊ/ and /ɪ/ distinctly. IPA anchors: US /ˌmaɪ.oʊˈfɪ.brɪ.lɚ/, UK /ˌmaɪ.əˈfɪ.brɪ.lə/, AU /ˌmaɪ.əˈfɪ.brɪ.lə/.
The prefix myo- derives from the Greek mys, mysos 'muscle', used in scientific terms to denote muscle tissue. Fibrillar comes from fibrilla, a diminutive form of fibra, Latin for fiber, and the -ar suffix forming adjectives. The combined form myofibrillar first appears in 19th–early 20th century anatomical literature as methods of describing the structural components of muscle fibers—myofibrils—began to be distinguished from other cytoskeletal elements. The term emphasizes fiber-like units within muscle cells (myofibrils) that run along the length of muscle fibers and’re essential for contraction. Over time, myofibrillar was extended to contexts referencing related pathological disorganization, such as myofibrillar myopathy, and broader structural descriptions of muscle tissue. First known usage in English scientific texts traces to comparative anatomy and physiology works from late 1800s, with increasingly precise usage as muscle histology advanced, especially in the mid-20th century when electron microscopy clarified myofibrillar architecture.
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Words that rhyme with "myofibrillar"
-ral sounds
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