2 syllables: myo, blast. Stress on myo.
MEYE-oh-blast
/ˈmaɪoʊblæst/
myoblast is pronounced MEYE-oh-blast (/ˈmaɪoʊblæst/). It has two syllables (myo-blast), with the stress on "myo". Myoblast is a primitive muscle-forming cell that fuses with others to create muscle fibers during development and repair. It originates from mesodermal lineage and differentiates into myocytes; the term is used in biology and medicine to describe precursor cells involved in muscle formation and regeneration. In research contexts, myoblasts are studied to understand muscular disorders and tissue engineering.
Myoblast is a primitive muscle-forming cell that fuses with others to create muscle fibers during development and repair. It originates from mesodermal lineage and differentiates into myocytes; the term is used in biology and medicine to describe precursor cells involved in muscle formation and regeneration. In research contexts, myoblasts are studied to understand muscular disorders and tissue engineering.
- You might rush the middle syllable and merge /ə/ with the adjacent vowels, making it sound like /ˈmaɪ.æˌblæst/. Take a beat after /maɪ/ to let the schwa land. - Another error is dropping the /ə/ entirely, leading to /ˈmaɪblæst/ or /ˈmaɪɪblæst/; keep the middle schwa brief but audible. - Some speakers over-emphasize the second syllable, producing /ˈmaɪ.əˈblæst/ with an awkward pause; instead, keep a steady three-syllable flow and even timing. - The final /blæst/ can be misarticulated as /blæst/ with a softened /t/ or a detached /t/ sound; aim for a crisp, released /t/ or a lightly aspirated ending depending on dialect.
"During embryogenesis, myoblasts migrate and align to form the early muscle segments."
"In culture, satellite cells can be induced to activate and become myoblasts for regenerative therapies."
"The study compared myoblast differentiation under different growth factors to optimize muscle repair."
You say /ˈmaɪ.əˌblæst/ in US English, with primary stress on the first syllable and secondary stress on the third. The syllables break as MY-uh-BLAST, where /maɪ/ sounds like ‘my’, /ə/ is a quick schwa, and /blæst/ rhymes with ‘forecast’ without the long vowel. In careful speech, ensure the /bl/ cluster is clear and avoid turning the /æ/ into a broader vowel. Audio resources like Forvo or Pronounce can provide native-adjacent examples.
Common errors include misplacing the stress (saying my-ó-blast) and mispronouncing the medial /ə/ as /ɪ/ or a full /ɜː/. Some speakers fuse the second and third syllables, producing /ˈmaɪæˌblæst/ or a flattening /ˈmaɪəblæst/. Correct it by practicing the three-syllable rhythm and ensuring the schwa remains brief. Focus on maintaining the /bl/ onset of the final syllable and not skipping the /ə/ entirely.
In US English, /ˈmaɪ.əˌblæst/ with a pronounced schwa in the middle. UK English keeps a similar pattern but may reduce the middle vowel slightly closer to /ɪ/ or /ə/, yielding /ˈmaɪ.əˈblɑːst/ in careful speech, with a more open /ɑː/ for the final syllable. Australian takes a more centralized vowels in the unstressed syllable, sometimes giving /ˈmaɪ.əˌblæst/ with slightly flatter intonation and a shorter final vowel. Across all, the final /t/ is crisp in careful speech and may be unreleased in fast talk.
The difficulty comes from the tri-syllabic structure and the clear /bl/ onset in the last syllable, plus the distinct /ə/ (schwa) that often reduces in rapid speech. The sequence /maɪ.ə/ demands a poised transition between a diphthong and a schwa, and the final /blæst/ requires crisp consonant timing between /b/ and /l/; many speakers blend the consonants or shorten vowels, reducing intelligibility in technical discussions.
There are no silent letters in the standard pronunciation. The trickiness lies in the three-syllable rhythm and accurate vowel placement: /ˈmaɪ.əˌblæst/. You’ll want to articulate the /bl/ cluster clearly and not drop the middle /ə/. Practicing with minimal pairs like myo- variant words can help solidify the pattern and avoid silent-letter misconceptions.
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- US: maintain a clear schwa /ə/ in the middle; the final /æst/ is relatively lax but still crisp. IPA guide: /ˈmaɪ.əˌblæst/. - UK: may reduce the middle vowel slightly and lean on /ɒ/ in the last syllable if the speaker has a broad accent; aim for /ˈmaɪ.əˈblɑːst/ in careful speech, with a more open vowel in the final syllable. - AU: tends toward slightly shorter vowels in the unstressed middle and a strong final /æst/ or /ɑːst/ depending on region; practice with /ˈmaɪ.əˌblæst/ and adjust to your local tendencies. - IPA references: US / maɪ.əˈblæst, UK / maɪ.əˈblɑːst, AU / maɪ.əˈblæst/. - Pro tip: keep teeth lightly apart for /aɪ/ diphthong, relax the jaw for the schwa, then snap the /bl/ onset sharply.
The term myoblast comes from the Greek mys-, meaning muscle, and blastē, meaning germ or bud, together signaling a germ cell that forms muscle tissue. The earliest use traces to 19th-century anatomical literature when scientists began classifying distinct muscle-forming cells. The root mys- collapses with myo- in later medical English, preserving the sense of “muscle-related.” blast-, from blast- meaning germinal or bud-like growth, appears in embryology (e.g., blastula). Over time, myoblast was adopted to denote mesoderm-derived precursors with the capacity to proliferate and fuse into multinucleated muscle fibers (myotubes). In modern biotechnology, the term persists in both developmental biology and regenerative medicine to describe cells capable of myogenesis in vitro and in vivo. By the late 20th century, the word became standard in muscle biology in textbooks and research articles, often appearing in phrases like primary myoblasts, immortalized myoblast lines, and satellite cell–derived myoblasts, reflecting both lineage origin and functional role in muscle formation and repair.
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Words that rhyme with "myoblast"
-ost sounds
-ast sounds
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