4 syllables: mo, no, so, my. Stress on so.
moh-nuh-SOH-mee
/ˌmoʊnəˈsoʊmi/
monosomy is pronounced moh-nuh-SOH-mee (/ˌmoʊnəˈsoʊmi/). It has four syllables (mo-no-so-my), with the stress on "so". Monosomy is a chromosomal condition in which a diploid cell has only one copy of a particular chromosome instead of the usual two. It is a form of aneuploidy and can lead to developmental abnormalities or miscarriage, depending on which chromosome is affected. The term is commonly used in genetics, medicine, and prenatal diagnoses, and is often contrasted with monosomy rescue and trisomy conditions.
Monosomy is a chromosomal condition in which a diploid cell has only one copy of a particular chromosome instead of the usual two. It is a form of aneuploidy and can lead to developmental abnormalities or miscarriage, depending on which chromosome is affected. The term is commonly used in genetics, medicine, and prenatal diagnoses, and is often contrasted with monosomy rescue and trisomy conditions.
"In genetics, monosomy of chromosome 13 is a recognized, though rare, event."
"The patient’s karyotype revealed monosomy for chromosome 18, explaining some of the congenital anomalies."
"Researchers study monosomy to understand how gene dosage affects development."
Pronounce as /ˌmɒ.nəˈsoʊ.mi/ in US and /ˌmɒn.əˈtəʊ.mi/ in UK. Stress falls on the second syllable in most analyses: mo-NO-so-my, with a clear long 'o' in the penultimate syllable. The initial 'mono-' reduces to 'mo' or 'mun' sound depending on accent, followed by 'so' with a long o, and ends with '-my' as /mi/. Try saying it slowly: MO- nuh-SOH-mee; then speed up to natural rhythm. Audio reference: consult medical pronunciation resources or Forvo entries for 'monosomy.'
Common errors include misplacing the primary stress (trying to stress 'mo' or 'so' unevenly) and mispronouncing the second syllable as 'noh' instead of 'nuh-.' Another frequent issue is turning the final 'my' into a 'mee' in isolation or adding an extra syllable in non-native speakers. Correction: place primary stress on the third syllable: mo-NO-so- my, with /ˈmi/ ending. Practice by splitting into syllables: /ˌmɒ.nəˈsoʊ.mi/ and exaggerate the second syllable to feel where the stress lands. Listening to native medical speakers helps lock the pattern.
US tends to use /ˌmɒ.nəˈsoʊ.mi/ with rhotic clarity on the 'r' not present, and the final 'y' is /i/. UK often shows a slightly more clipped /ˌmɒn.əˈtəʊ.mi/ with less rhotic influence and a longer 'o' in the penultimate syllable; the second syllable may be reduced to /ə/ or /ɪ/. Australian pronunciation usually mirrors UK but with more vowel reduction in connected speech, yielding /ˌmɒ.nəˈsəʊ.mi/ or /ˌmɒn.əˈsoʊ.mi/ depending on speaker. Focus on the 'so' diphthong: US /soʊ/ vs UK/Au /təʊ/ or /səʊ/; final /mi/ remains stable. For precise reference, listen to YouGlish examples across regions.
The difficulty comes from the three-syllable stress pattern in an unfamiliar perceived rhythm, plus two consecutive vowels in the second syllable that can be mispronounced as /nɪ/ or /noʊ/ depending on speaker. The challenge lies in accurate syllable timing and the long diphthong in the penultimate syllable. Focus on keeping the stress on the third syllable and ensuring the 'so' has a true long 'o' sound. Practice with slow slowed articulation and phoneme isolation: /ˌmɒ.nəˈsoʊ.mi/.
No silent letters in standard pronunciation. The three vowel groups map clearly to syllables: 'mo' (/mɒ/ or /mɒn/ depending on accent), 'so' (/soʊ/ or /təʊ/), and 'my' (/mi/). The potential pitfall is not recognizing that the 'o' in the middle is part of the stressed syllable; misplacing stress can make the word sound awkward. Remember the main stress is on the third syllable: mo-NO-so-my, with the 'so' diphthong carrying the strongest vowel quality.
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The word monosomy combines the prefix mono- meaning 'one' with -somy from the Greek soma meaning 'body' via French/Latin roots in medical terminology. Its ancestor terms appear in 19th- and 20th-century chromosomal nomenclature when scientists formalized concepts of aneuploidy. The earliest uses traced in contemporary literature appear in cytogenetics texts of the 1960s and 1970s, as karyotyping revealed conditions like monosomy and trisomy. 'Mono-' is widely used in biology (monocot, monoculture); 'somy' (from soma, 'body') appears in aneuploid counseling, karyotype reporting, and clinical genetics. Over time, monosomy has become a standard descriptor for the loss of a single chromosome copy, distinct from more severe losses like nullisomy. The term’s clinical nuance—whether monosomy is compatible with life—has been refined through newborn screening, prenatal diagnostics, and case studies, broadening its usage beyond theoretical genetics to patient communication and counseling.
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Words that rhyme with "monosomy"
-omy sounds
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