2 syllables: En, zymes. Stress on En.
EN-zeyemz
/ˈɛˌnzaɪmz/
Enzymes is pronounced EN-zeyemz (/ˈɛˌnzaɪmz/). It has two syllables (En-zymes), with the stress on "En". Enzymes are biological molecules that act as catalysts to accelerate chemical reactions within living organisms, typically proteins though some RNA molecules also have catalytic properties. They are essential for digestion, metabolism, and numerous cellular processes, and work by lowering the activation energy required for reactions. Enzymes are highly specific for their substrates and operate under optimal conditions of temperature and pH.
nounEnzymes are biological molecules that act as catalysts to accelerate chemical reactions within living organisms, typically proteins though some RNA molecules also have catalytic properties. They are essential for digestion, metabolism, and numerous cellular processes, and work by lowering the activation energy required for reactions. Enzymes are highly specific for their substrates and operate under optimal conditions of temperature and pH.
How to Pronounce Enzymes
"The enzyme amylase in saliva begins starch digestion in the mouth."
"Lactase is an enzyme that helps break down lactose in the small intestine."
"Catalase is an enzyme that accelerates the breakdown of hydrogen peroxide into water and oxygen."
Pronounce as EN-zymes with stress on the first syllable. IPA: US/UK/AU /ˈɛnzaɪmz/. Start with a clear short E sound, then n as in 'net', followed by a stressed /zaɪ/ (like 'zai' as in 'zine'), and finish with /mz/ where m precedes z. Keep the mouth in a relaxed position for the z, avoiding a hissier s. You can practice by saying ‘EN-zai-mz’ slowly, then blend to natural speed. Audio references: Cambridge/Oxford dictionaries provide native pronunciations; Pronounce app and Forvo offer speaker recordings.
Two common errors: (1) Misplacing emphasis, saying /ˈɛnzɪmz/ with reduced vowel in the second syllable. (2) Slurring the /zaɪ/ into a hard /za/ or mispronouncing the final /ɪmz/ as /ɪmz/ without the clear /aɪ/ diphthong. Correction: keep the /zaɪ/ as a distinct diphthong /zaɪ/ and keep the final /mz/ clearly voiced, ensuring /z/ before /m/ is audible. Practice by isolating /ˈɛn/ + /zaɪ/ + /mz/ and using minimal pairs like “enzymes” vs “enzymic” to check the vowel quality.
Across US/UK/AU, the primary difference lies in rhoticity and vowel quality rather than the core consonants. US and AU are rhotic, but most speakers produce /ˈɛnzaɪmz/ with a clearly pronounced /r/ not present here, so minimal rhotic variation. UK typically has less vowel rounding in the /aɪ/ diphthong and might show subtle length differences. In all, the pronunciation remains /ˈɛnzaɪmz/ with stress on the first syllable; accent-driven changes are minor in the final /mz/ cluster.
The difficulty comes from the uncommon final consonant cluster /mz/ after a stressed diphthong, and the /zaɪ/ diphthong with precise tongue height. Non-native speakers often misplace the /z/ voice or merge /ɪ/ into /iː/. Focus on articulating /z/ with a clear voice onset before /m/ and keep /aɪ/ distinct. Practice saying /ˈɛn/ then /zaɪ/ then /mz/ slowly, then increase speed. IPA cues: /ˈɛn.zaɪmz/.
The unique challenge is the combination of the stressed syllable onset with a diphthong followed by a voiced alveolar nasal+voiced bilabial fricative cluster /mz/. Learners tend to insert an extra vowel or mispronounce /z/ as /s/. Tackle this by practicing the exact sequence /ˈɛn/ + /zaɪ/ + /mz/ with slow tempo, and use a tongue position guide: keep the tongue high-mid for /zaɪ/, tip behind the upper teeth for /z/, and close lips for /m/ immediately before the /z/.
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The word enzyme comes from the Greek word enzymos, meaning yeast on leaven or in leavened dough; in 1878, Eduard Buchner demonstrated that fermentation could occur without living cells, coining the term enzyms (later standardized to enzyme). The root en- (“in”) and zyme (from zymein, “to ferment”) reflect the idea of fermentation catalysts. Over time, the term broadened to describe biological catalysts beyond fermentation. In the modern lexicon, enzyme specifies a biological protein or RNA catalyst that accelerates chemical reactions, typically with highly specific substrate binding at active sites. The usage evolved from generic “ferments” to precise biochemical agents, with the pluralization “enzymes” established in scientific literature by the early 20th century. Today, “enzyme” denotes a fundamental concept across biochemistry, physiology, medicine, and industrial biotechnology, embedded in terms like protease, ligase, and polymerase, each naming a class of catalytic enzymes with distinct mechanisms. First known uses appeared in late 19th-century German and English scientific writings, reflecting the rapid growth of enzymology during that era.
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Words that rhyme with "Enzymes"
-ses sounds
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