3 syllables: Ar, gi, nine. Stress on gi.
ahr-JIN-een
/ɑɹˈdʒɪniːn/
Arginine is pronounced ahr-JIN-een (/ɑɹˈdʒɪniːn/). It has three syllables (Ar-gi-nine), with the stress on "gi". Arginine is an essential amino acid that the body uses to synthesize proteins and nitric oxide. It is a basic, positively charged molecule important for immune function and wound healing. In biochemistry contexts, arginine’s side chain (guanidino group) participates in multiple enzymatic and signaling processes.
nounArginine is an essential amino acid that the body uses to synthesize proteins and nitric oxide. It is a basic, positively charged molecule important for immune function and wound healing. In biochemistry contexts, arginine’s side chain (guanidino group) participates in multiple enzymatic and signaling processes.
How to Pronounce Arginine
"The laboratory study measured how arginine supplementation affected nitric oxide production."
"Arginine is commonly used in research on cardiovascular health and immune response."
"Some medical conditions require monitoring arginine levels in the bloodstream."
US: /ˌɑːrˈɡiːniːn/ or /ˌɑːrˈɪniːn/; UK: /ˌɑːˈdʒɪniːn/ or /ˌɑːˈɡɪniːn/; AU: typically /ˌɑːˈɡɪniːn/. The primary stress lands on the second syllable: ar-GIN-een, with the final -ine pronounced as a long ee sound. Articulate the “ar” as a strong, open-front vowel, follow with a clear /ɡ/ then a long /iː/ for -in- and a final /n/. For clarity in lab contexts, say AR-gih-neen quickly but without collapsing syllables. Audio reference: imagine saying “AR-gene” but with a long -een at the end.
Two frequent errors: (1) misplacing stress, saying ar-GI-neen with stress on the first syllable; (2) pronouncing the middle segment as /ɪ/ or /i/ without the proper /ɡ/ onset or mispronouncing the final -ine as /ɪn/ instead of /iːn/. Correction: emphasize the second syllable with /ˈɡɪ/ or /ˈɡiː/ depending on accent, then glide to /niːn/. Keep the initial /ɑː/ or /ä/ sound open and avoid slurring the 'rg' cluster. IPA guidance: US /ˌɑːrˈɡiːniːn/; UK /ˌɑːˈɡɪniːn/; AU /ˌɑːˈɡɪniːn/.
US tends to keep a strong rhotic /r/ and a long /iː/ in -ine; UK often reduces the third vowel slightly, with /ˈɒr/ or /ˈɑːɹ/ and /ɪ/ or /iː/ depending on speaker, and AU usually follows UK patterns but with a more open /ɐ/ in some speakers. The stress generally sits on the second syllable. In all, the key is the /ɡ/ cluster and the final /iːn/: US may make /r/ more pronounced, UK and AU may have a shorter or tenser final vowel before /n/. IPA references: US /ˌɑːrˈɡiːniːn/, UK /ˌɑːˈɡɪniːn/, AU /ˌɑːˈɡɪniːn/.
The difficulty stems from the consonant cluster /ˈɡ/ after the vowel, plus the long final vowel /iːn/ that can be shortened in fast speech. Additionally, English tends to reduce unstressed vowels, which can blur the /niːn/ ending into /nɪn/ in casual speech. Mastery requires precise lip-tunch and tongue positioning: keep the back of the tongue high for the /g/, open the jaw for /ɑː/ and maintain a long, tense /iː/ before /n/.
In some contexts, speakers insert a subtle schwa before the final -ine, yielding ar-GI-nee-n or ar-GIN-ee-n depending on the pace. The scientifically precise form uses a clean, unstressed /ɪ/ or /iː/ in the second syllable before the final /iːn/. Focus on distinguishing /ɡ/ from /dʒ/ in careful enunciation as lab terms often cause confusion with words like 'arginine' and 'arginase'; the correct featural cues are the hard /g/ and the long -ine vowel.
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US: rhotic /r/ is pronounced; maintain a full /ɑː/ before /r/; the /ɪ/ is shorter; final /iːn/ is slower than the middle vowel. UK: less rhotic /r/, more clipped /ɡ/; /ɪ/ vs /iː/ depends on speaker; final /iːn/ can be slightly longer than mid vowels. AU: often a broader /ɔː/ or /ɒ/ initial, with a clear /ɡ/; final /iːn/ close to UK, but with a more open jaw and sometimes stronger vowel onset. IPA references: US /ˌɑːrˈɡiːniːn/, UK /ˌɑːˈɡɪniːn/, AU /ˌɑːˈɡɪniːn/; pay attention to rhoticity and vowel length differences.
Arginine derives from the Greek arginos meaning silver-colored, with the chemical suffix -ine used for nitrogen-containing compounds and amino acids. The term entered scientific usage in the 19th century as chemists identified amino acids and their structures. Its naming reflects the historical practice of linking amino acids to amino groups and chemical properties. The amino acid arginine was distinguished from other amino acids through studies of protein composition and later through structure elucidation in the early 20th century. Over time, arginine has become central in biochemistry because its positively charged side chain participates in guanidino chemistry, nitric oxide synthesis, and regulation of urea cycle intermediates. First known use in publications appeared in the late 1800s when early biochemists started cataloging amino acids; however, systematic characterization and standardization of the 20 standard amino acids solidified its canonical name and symbol (Arg).
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Words that rhyme with "Arginine"
-ine sounds
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