3 syllables: an, ti, gens. Stress on an.
AN-tij-uhnz
/ˈæntɪdʒənz/
antigens is pronounced AN-tij-uhnz (/ˈæntɪdʒənz/). It has three syllables (an-ti-gens), with the stress on "an". Antigens are molecules or parts of molecules that the immune system recognizes as foreign. They trigger an immune response, prompting the body to produce antibodies. In biology, antigens are often proteins or polysaccharides on pathogens, cells, or toxins, and they can elicit targeted immune reactions for defense or vaccination purposes.
Antigens are molecules or parts of molecules that the immune system recognizes as foreign. They trigger an immune response, prompting the body to produce antibodies. In biology, antigens are often proteins or polysaccharides on pathogens, cells, or toxins, and they can elicit targeted immune reactions for defense or vaccination purposes.
- You will hear and see two common pitfalls: first, misplacing the stress on the second syllable, yielding AN-TI-gen; keep stress on the first syllable AN-ti-; second, mispronouncing the /dʒ/ as /j/ or /ʒ/, which softens the post-alveolar stop; correct by aiming for a tight transition from /t/ to /dʒ/ and rounding the tongue blade for the affricate. - 3 tips: slow down the sequence /æ n t ɪ d ʒ ɛ n z/ in isolation, practise minimal pairs like ant-igen with 'ant' and 'jence', then blend at natural speed. - Record yourself reading typical immunology phrases to hear if the final /z/ stays voiced and not devoiced. - Keep jaw relaxed, avoid tensing the lips; keep vowel sounds crisp and short for the stressed syllable.
"The lab identified several antigens present on the surface of the bacterial strain."
"Researchers studied how different antigens influence antibody production in mice."
"The vaccine contains epitopes that act as antigens to stimulate immunity."
Pronounce as AN-ti-jens. IPA US/UK roughly /ˈæn.tɪ.dʒɛn(z)/ with the final z optionally devoiced in careful speech. Primary stress on the first syllable. Tip: start with /æ/ as in cat, then /n/; follow with a quick /tɪ/ for the second syllable and end with /dʒɛn(z)/ as in 'jenn' but with a soft /z/. Listening reference: Cambridge/Oxford entries show /ˈæn.tɪ.dʒɛn/; Forvo recordings confirm natural speakers.
Common errors: 1) misplacing stress on the second syllable (AN-ti-genz instead of AN-ti-jenz). 2) pronouncing /dʒ/ as /j/ or /tʃ/ leading to /æ n t ɪ jɛn z/ or /æ n tɪ dʒɛn/. 3) devoicing the final /z/ to /s/ in careful speech, or adding extra syllables. Correction: keep primary stress on first syllable, use /dʒ/ cluster for the third phoneme, and pronounce final /z/ as voiced unless the context dictates voiceless in rapid speech.
US: /ˈæn.tɪ.dʒɛn(z)/ with clear /æ/ in first vowel and rhotic neutral. UK: /ˈæn.tɪ.dʒen(z)/ often with slightly shorter /æ/ and non-rhotic r-less ending; AU: /ˈæn.tɪ.dʒənz/ with a schwa-like in the final syllable depending on speaker, and a rolled or flapped /t/ in some Australian accents.
Two phonetic challenges: /æ/ vowel in the first syllable can be tense for non-native speakers; the /dʒ/ sound in the third consonant cluster requires a precise palate placement combining /d/ with /ʒ/. Finally, the final /z/ can be devoiced in rapid speech, making it sound like /s/. Practice the tip: hold the /æ/ with relaxed jaw, release a clear /dʒ/ before the final /ɛn(z)/ to feel the bridge between syllables.
A unique, user-focused angle: Do you pronounce the 'g' in antigens as a soft /dʒ/ or a simple /d/? In standard pronunciation, the segment is /dʒ/ after the /t/ onset, forming the /tɪ.dʒ/ sequence; think of it as a blend where /t/ and /dʒ/ flow into a single affricate in quick speech. This is a natural feature of the word, not a separate letter sound; listen for the slight click between /t/ and /ɪ/ and the rapid move to /dʒ/.
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- US: maintain rhoticity in connected speech; /æ/ in first syllable is tense; final /z/ clearly voiced in careful speech. - UK: non-rhotic alignment; similar /æ/ and /dʒ/ but smoother liaison across syllables; final /z/ closer to /z/ in careful speech. - AU: tends toward a slightly more centralized vowel in /æ/ and broader /ənz/ ending; some speakers insert a near-schwa in the final syllable; be mindful of a slightly softer onset to /dʒ/ in rapid speech. Use IPA references: US /ˈæn.tɪ.dʒɛn(z)/, UK /ˈæn.tɪ.dʒɛn(z)/, AU /ˈæntɪ.dʒənz/; focus on vowel length and final consonant voicing.
Antigen derives from the Greek anti- ‘against’ and genes ‘created or produced’, from geneein ‘to be born’ via Latin antigenum, meaning a thing that produces an immune response. The term entered English medical vocabulary in the early 20th century as immunology formalized, with antigen used to denote any substance capable of provoking an immune reaction. Its sense refined alongside humoral immunity and cellular immunity, where specific proteins or polysaccharides on pathogens or toxins act as antigens. Over time, the concept broadened to include autoantigens in autoimmune conditions and tumor-associated antigens in cancer biology. First recorded use appears in medical literature around the 1910s-1920s, reflecting the shift toward understanding host-pathogen interactions at the molecular level. As diagnostics and vaccines advanced, antigen terminology became standard in immunology, biochemistry, and clinical practice, remaining central to disease detection, immunoassays, and immunotherapy.
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Words that rhyme with "antigens"
-ngs sounds
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