Adiponectin is a protein hormone produced by fat cells that regulates glucose levels and fatty acid breakdown. It plays a key role in metabolic processes and insulin sensitivity, with higher levels generally linked to better metabolic health. In research, adiponectin is studied for its anti-inflammatory and cardioprotective effects.
US: /ˌædɪpoʊˈnɛktɪn/ emphasise the diphthong /oʊ/ in po; non-rhotic tendencies may reduce /r/. UK/AU: /ˌædɪpəˈnɛktɪn/ with less pronounced /oʊ/ and more centralized vowel in second syllable; ensure /ɪ/ in first and final syllables remains crisp. Both regions maintain four syllables; focus on /nɛk/ as the nucleus. IPA anchoring: US /æ/ + /dɪ/ + /poʊ/ + /ˈnɛk/ + /tɪn/; UK/AU /æ/ + /dɪ/ + /pə/ + /ˈnɛk/ + /tɪn/.
"Researchers measured adiponectin levels in the blood to assess metabolic health."
"In adipose tissue, adiponectin is secreted by adipocytes and circulates in the bloodstream."
"Low adiponectin is associated with obesity and type 2 diabetes."
"The adiponectin signaling pathway influences lipid metabolism and insulin sensitivity."
Adiponectin derives from Greek adip-, meaning “fat,” and -onectin, from the chemical suffix -nectin (often used in protein names) with the sense of a factor or substance. The term is constructed to reflect its origin from adipose tissue (fat) and its role as a circulating protein (hormone). The earliest usage in scientific literature appears in the late 1990s as researchers identified adiponectin as a newly characterized adipokine involved in metabolic regulation. Its discovery came from studies of adipose-derived hormones with anti-inflammatory and insulin-sensitizing properties, distinguishing it from other adipokines. Over time, adiponectin has become central in metabolic disease research, with extensive work detailing its multimodal signaling through receptors AdipoR1 and AdipoR2 and its paradoxical decrease in obesity despite high adipose mass.
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Words that rhyme with "Adiponectin"
-tin sounds
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Pronounce as /ˌædɪpoʊˈnɛktɪn/ (US) or /ˌædɪpəˈnɛktɪn/ (UK/AU). Stress falls on the third syllable: a‑di‑po‑NEK‑tin. Begin with /ˈæ/ in first syllable, then /dɪ/ or /də/; the “po” is tied to /poʊ/ or /pə/. End with /nɛk.tɪn/. Mouth position: lips relaxed, tongue high-mid for /eɪ/ or /eɪ̯/ in /poʊ/, then a clear onset of /n/ before /ɛ/.
Common errors: (1) misplacing stress on the second or fourth syllable; (2) confusing /poʊ/ with /pə/ and producing /ˈædɪpəˈnɛktɪn/ instead of /ˌædɪpoʊˈnɛktɪn/. Correction: keep primary stress on the syllable with /nɛk/; articulate /poʊ/ as a single tense vowel, not a reduced /po/. Finally, avoid turning the ending into /-ɪn/ as in “kin”; keep /-tɪn/.”,
US: /ˌædɪpoʊˈnɛktɪn/ with rhoticity and a rounded /poʊ/. UK/AU: /ˌædɪpəˈnɛktɪn/ with less rhotic influence in some regions and a shorter /ə/ in second syllable. Both share /nɛk.tɪn/ ending; ensure clear /n/ before /ɛ/ and avoid flapping. IPA guides indicate the main difference is /poʊ/ vs /pə/ and stress on the /nɛk/ syllable.
The difficulty comes from the multi-syllabic structure with four syllables and a non-intuitive vowel sequence: /æ/ then /ɪ/ then /poʊ/ or /pə/ then /ˈnɛk/ then /tɪn/. The cluster /dn/ is not present; you must sequence /d/ + /ɪ/ smoothly and maintain primary stress on the -nɛk- syllable. Also, the suffix -nectin is not pronounced like “kin.” Focus on the liquid/diphthong transitions and steadiness of the final /tɪn/.
There are no silent letters in standard pronunciation; every letter contributes to the four-syllable rhythm. Syllable count is four (a-di-po-nectin). The only potential confusion arises from vowel reductions in connected speech, but no letter is silent in careful articulation.
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