4 syllables: A, cy, clo, vir. Stress on cy.
uh-SIK-loh-vir
/əˈsɪkloʊˌvɪɹ/
Acyclovir is pronounced uh-SIK-loh-vir (/əˈsɪkloʊˌvɪɹ/). It has four syllables (A-cy-clo-vir), with the stress on "cy". Acyclovir is an antiviral medication used to treat infections caused by herpes viruses. It works by inhibiting viral DNA replication, helping to reduce symptoms and transmission. In medical contexts it is prescribed systemically or topically, and its pronunciation is often challenged by its multi-syllabic structure and clinical spelling.
nounAcyclovir is an antiviral medication used to treat infections caused by herpes viruses. It works by inhibiting viral DNA replication, helping to reduce symptoms and transmission. In medical contexts it is prescribed systemically or topically, and its pronunciation is often challenged by its multi-syllabic structure and clinical spelling.
How to Pronounce Acyclovir
"The patient was prescribed acyclovir to treat shingles."
"Acyclovir is commonly used in the management of herpes simplex outbreaks."
"She researched the proper dosage of acyclovir for her infection."
Pronounce as /ˌeɪ.saɪˈkloʊ.vɪr/ (US) or /ˌeɪˈkləʊ.vɪə/ (UK). Start with 'ay' as in 'ay,' then 'sigh' for 'sy' sound, stress on the 'klo' syllable, and end with 'veer' like 'peer' but with a v. The oops-free rhythm is a-sigh-CLOH-veer. IPA helps: /ˌeɪ.sɪˈkloʊ.vɪr/ can be heard in medical dictation audio references; you can compare with audio dictionaries to verify the 'klo' cluster.
Two frequent errors: (1) stressing the wrong syllable, often placing primary stress on 'cy' or 'vir' instead of 'kloh'; (2) mispronouncing 'cyclo' as 'sik-lo' or dropping the 'oi' diphthong, giving a clipped 'clo-veer.' Correction: emphasize the 'kloh' segment with a clear 'k' plosive and a long 'oh' vowel, ensure the initial 'ay-sigh' lead-in is smooth, and keep the final 'vir' as a voiced 'ver' with a short 'i' like 'veer'.
US: /ˌeɪ.saɪˈkloʊ.vɪr/ with rhotic 'r' in all positions; UK: /ˌeɪˈkləʊ.vɪə/ where the 'cy' may be more 'si' sound and the final 'vir' can become 'veer' or 'vi-uh' depending on speaker; AU: /ˌeɪˈklɒ.vɜː/ with non-rhotic approximation; vowel qualities shift: US tends to a clearer 'oh' in 'clo', UK slightly more centralized or diphthongized, AU more open 'o' and a schwa in the final syllable.
The difficulty comes from multiple factors: a multisyllabic, medical term with a three-consonant cluster (cycl-), the 'cy' digraph yielding a 'sai' or 'si' sound, and the trailing 'vir' that can slip into 'ver' or 'veer' depending on accent. The presence of a diphthong in the first two syllables and the need to keep stress accurate on the middle-stressed syllable adds to the challenge. Using IPA helps anchor pronunciation and practicing with native medical speakers reduces ambiguity.
Is there a commonly confused spelling when pronouncing Acyclovir that leads to misaccentuation, such as 'acyclovir' vs 'acyclovir'? The unique issue is the 'cyclo' part; learners may misplace the stress on 'cy' or mispronounce 'lo' as a short 'o' rather than a long 'o'. To avoid errors, rehearse the rhythm: ay-sigh-CLOH-veer, and compare with dictionary pronunciations that provide audio. Focus on the diphthong in 'ay' and the long 'o' in 'clo'.
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Acyclovir derives from the prefix a- (not) + cyclo- (ring or cycle, reflecting the nucleoside analogue structure) + -vir (virus). The term emerged in the 1980s as pharmacology advanced antiviral nucleoside analogues. Its construction mirrors classic drug-naming conventions: a prefix denoting mechanism, a core indicating chemical class, and a suffix signaling antiviral activity. The medical literature records its use in clinical practice beginning in the 1980s, with rapid adoption in antiviral therapy for herpes simplex and varicella-zoster infections. The root cyclo- evokes the cyclic sugar-like framework of the molecule, while vir signals antiviral action, aligning with other antivirals such as zidovudine and acyclovir’s progenitors. The word’s literal components are often misread due to its unusual vowel sequence and syllable structure for non-medical speakers, reinforcing the value of precise pronunciation in clinical settings.
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💡 These words have similar meanings to "Acyclovir" and can often be used interchangeably.
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Words that rhyme with "Acyclovir"
-ver sounds
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