Syracuse is a proper noun referring to a city in upstate New York (and to other places named after the Italian city). In American usage it typically bears the stress on the first syllable and ends with a soft “-s” sound; the pronunciation blends a short “si” with a reduced “-ra-” and a final “k” or “s” sound, depending on context. It’s a multi-syllabic name that can be pronounced with a strong initial vowel and a crisp terminal consonant in careful speech.
Full pronunciation guide