St Giles is a proper noun referring to a location or street name (notably a district in London and St Giles' Cathedral in Edinburgh). It is pronounced as two syllables in most uses: /ˌseɪnt ˈɡaɪlz/ or /ˈsaɪnts ˈɡaɪlz/ depending on whether you treat it with apostrophes as a possessive/place name or retain the stand-alone words. In running speech, the initial cluster often reduces to a clear Saint (St) followed by Giles, with stress on the second word in many English variants.
Full pronunciation guide