Sirtuins are a family of NAD+-dependent deacetylase enzymes that regulate aging, metabolism, and stress resistance in cells. They act as protein deacetylases and ADP-r-ribosyltransferases, influencing gene expression and mitochondrial function. The term encompasses several homologous proteins (e.g., SIRT1–SIRT7) that play key roles in longevity research and cellular health.
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