Calcineurin is a large calcium/calmodulin-dependent serine/threonine phosphatase that plays a central role in activating T-cells of the immune system. The enzyme is abundant in many cell types and is a key mediator in intracellular signaling, becoming active in response to increased intracellular calcium. Its name derives from its calcium/calmodulin activation and relation to phosphatase activity, with clinical relevance to transplant medicine and immunology research.
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